以β－内酰胺类药物为代表的抗生素的抗药机制和细菌耐药性.PPTVIP

β- Lactamase Inhibitor 第5小组成员： 李晓雪、买红霞、涂洋智、刘杰克、李凡、 李春雨、胡燕青、陈宝清、刘春煜、 薛璐琪、曾彦彰、陈文杰 PPT.制作讲解：海洋 Logical Line 1)Overview 2)Resistance of β- Lactam Antibiotics 3)Classification Mechanism of β-Lactamases 4)β- Lactamase Inhibitor 5)β- Lactam- β-Lactamase Inhibitor（combination） 6)Lessons Learned A Prespective Logical Line 1)Overview 2)Resistance of β- Lactam Antibiotics 3)Classification Mechanism of β-Lactamases 4)β- Lactamase Inhibitor 5)β- Lactam- β-Lactamase Inhibitor（combination） 6)Lessons Learned A Prespective 1)Overview Mechanisms： Disrupt the synthesis of the bacterial cell wall by interfering with the transpeptidase which catalyzes the cross linking process. Logical Line 1)Overview 2)Resistance of β- Lactam Antibiotics 3)Classification Mechanism of β-Lactamases 4)β- Lactamase Inhibitor 5)β- Lactam- β-Lactamase Inhibitor（combination） 6)Lessons Learned A Prespective 2)Resistance of β- Lactam Antibiotics Four primary mechanisms by which bacteria can overcome β-lactam antibiotics: Production of β-lactamase enzymes Changes in the active site of PBPs Decreased expression of outer membrane proteins(OMPs) Efflux Pumps β-lactamase ! Nearly 70 years ago, the first β-lactamase enzyme was identi?ed in Bacillus (Escherichia) coli before the clinical use of penicillin. E. P. Abraham and E. Chain described the phenomenon, but they are unable to isolate it. 4 years later, Kirby successfully extracted these cell-free “penicillin inactivators” from Staphylococcus aureus. β-lactamase ! The growing number of β-lactam antibiotics has since increased the selective pressure on bacteria, promoting the survival of organisms with multiple β-lactamases. Currently, more than 850β-lactamases are identified. Logical Line 1)Overview 2)Resistance of β- Lactam Antibiotics 3) Mechanism Classification of β-Lactamases 4)β- Lactamase Inhibitor 5)β- Lactam- β-Lactamase Inhibitor（combination） 6)Lessons Learned A Prespective Mechanism 3)Classification Mechanism of β-L