临床医学研究生课件-细胞与分子免疫学-03 Infection and Immunity-ok.pptVIP

Changes in bacteria Bacterial lipopolysaccharide (LPS) ----TLR 4 Viruse nucleic acid : dsRNA or unmethylated CpG motifs Membrane-bound PRRs Receptor kinases (discovered in plants) Toll-like receptors The mannose receptor Cytoplasmic PRRs NOD-like receptors (NLR) RNA Helicases Secreted PRRs Complement receptors Collectins (mannan-binding lectin) C-reactive protein lipid transferases peptidoglycan recognition proteins Pattern recognition receptors 模式识别受体 Viruses double-stranded RNA, poly I:C TLR 3 Numerous others Fungi zymosan (Beta-glucan) Host cells HSP70 Bacteria lipoteichoic acid Bacteria m