中西药联用风险因素评价与处方审核干预的探讨-中国药房.PDF

·药事管理· 中西药联用风险因素评估与处方审核、干预的探讨 ＊ 张华峰 ，宋 青，黄 进，秦 倪，韩蒙蒙，马超群，宋蒙妞，孟 瑶（解放军空军总医院药学部，北京 100142） 中图分类号 R95 文献标志码 A 文章编号 1001-0408（2015）16-2165-03 DOI 10.6039/j.issn. 1001-0408.2015.16.02 摘 要 目的：降低中西药联用风险，提高药物治疗的安全性和有效性。方法：根据风险管理的基本原理，识别和评估中西药联用 中的风险因素，加强对5种特殊人群处方、4类特殊药物处方的审核，并根据处方的不同风险等级采取不同干预措施，最后评价风 险管理效果。结果 ：我院通过上述风险因素的评估、处方的审核和干预等措施进行中西药联用风险管理，中西药联用门诊处方不 合格率从干预前（2012年3－6月）的1.68％下降到干预后（2014年3－6月）的0.42％，临床未见发生因中西药联用引起的严重不良 反应/不良事件。结论：引入风险管理模式可促进中西药联用处方审核的规范化与标准化。 关键词 中药；中成药；中西药联用；风险管理；不良反应；处方审核 Exploration of the Risk Assessment of the Combination of Traditional Chinese Medicine and Chemical Medicine and Prescription Review and Intervention ZHANG Hua-feng ，SONG Qing ，HUANG Jin ，QIN Ni ，HAN Meng-meng ，MA Chao-qun ，SONG Meng-niu ， MENG Yao （Dept. of Pharmacy ，Air Force General Hospital ，PLA ，Beijing 100142，China ） ABSTRACT OBJECTIVE ：To reduce the risk of the combination of traditional Chinese medicine and chemical medicine ，and to improve the safety and efficacy of medication. METHODS ：According to the basic principles of risk management ，the risk factors in the above-mentioned combination were identified and assessed ，the audit of prescriptions for 5 special groups and 4kinds of spe- cial drugs was strengthened ，different interventions were taken on the basis of the risk levels of prescriptions ，and finally the effect of risk management was evaluated. RESULTS ：Through the risk management of above-mentioned combination ，that included assess- ing the risk ，auditing and intervening the prescription ，the non-conformity rate of outpatient prescriptions for the combination in our hospital was decreased from 1.68％ （Mar.-Jun. 2012）befor the interventions to 0.42％ （Mar.-Jun. 2014）after the interventions ， and there was no clinically serious adverse reaction/adverse event. CONCLUSIONS ：The introduction of the risk management mod- el can promote the normalization and