Contraction of Skeletal Muscle骨骼肌收缩课件.pptVIP

Tubocurarine,α-bungarotoxin : block the N2-Ach receptor Neostigmine: inhibit AchE The Contraction Cycle: Detachment Detachment: New ATP binds to myosin heads Myosin heads detach from actin Transverse tubules (T tubule) connect plasma membrane of muscle cell to SR Section 4 Contraction of Skeletal Muscle 40 % of the body: skeletal muscle 10% of the body: smooth and cardiac muscle Classification of the Muscle: According to the structure: Striated Muscle, Smooth Muscle According to the Function: Skeletal Muscle, Cardiac Muscle, Smooth Muscle Skeletal Muscle Cardiac Muscle Smooth Muscle transmission of AP on nerve fiber transmission of excitation in Neuromuscular Junction transmission of AP in fibers （local current） Excitation-Contraction Coupling The Sliding Filament of Muscle Contraction 一、contraction of skeletal muscle Illustration of the Neuromuscular Junction (NMJ)  neuromuscular transmission Neuromuscular Junction Each nerve ending makes a junction called the neuromuscular junction, with the muscle fiber near its midpoint. There is only one such junction per muscle fiber. Motor end plate: The nerve fiber forms a complex of branching nerve terminals that invaginate into the surface of the muscle fiber but lie outside the muscle fiber plasma membrane. The entire structure is called motor end plate. 1. The structure of neuromuscular junction： ⑴prejunctional membrane: ①synaptic vesicle: ACh; ② Voltage-gated Ca2+ channel ； ⑵junctional cleft: 50nm，communication with extracellular fluid; ⑶postjunctional membrane:endplate membrane，①N2-Ach receptor;② AChE; New Ion Channel Players Voltage-gated Ca2+ channel in presynaptic nerve terminal mediates neurotransmitter release Nicotinic Acetylcholine Receptor Channel in muscle neuromuscular junction (postsynaptic membrane, or end plate) mediates electrical transmission from nerve to muscle End Plate Potential (EPP) The opening of Ach-gated channels is to a