桂芍知母汤加味治疗早期类风湿性关节炎临床疗效-中医内科学专业论文.docxVIP

成都中医药大学学位论文 成都中医药大学学位论文 PAGE PAGE 3 中文摘要 目的通过临床观察, 桂芍知母汤加味治疗早期类风湿性关节炎临床疗效。 方法观察桂芍知母汤加味治疗早期类风湿性关节炎的临床疗效，随机将符合 标准的早期类风湿性关节炎患者 40 例平均分为两组，治疗组 20 例，用中药桂芍 知母汤加味; 加上西药甲氨蝶呤。对照组 20 例，单用西药甲氨蝶呤加白芍总苷胶 囊，均用药一个疗程（一个月）。观察患着临床症状，体征评分、关节肿胀数、 治疗前后其评分的变化；观察治疗前后实验室检验指标的改善情况如类风湿因 子、血沉、C－反应蛋白 CCP 等。观察可能出现的不良反应等重要指标。 结果 1、临床疗效比较：治疗组总有效率为 94. 3%，显效率为 40%，对照组 总有效率为 90. 0%、显效率为 26. 7%；治疗组显效率明显优于对照组，治疗组疗 效总体分布优于对照组。 2、主要临床症状比较：两组治疗前后在关节压痛数、肿胀数、晨僵方 面均有显著疗效；治疗组优于对照组。 3、在改善实验室理化指标方面：治疗前后两组降低 RF、ESR、CRP 及 CCP 疗效显著, 治疗组优于对照组。 4、不良反应：治疗前后两组均无严重不良反应。 结论临床观察结果表示桂芍知母汤加味治疗早期类风湿性关节炎能缓解关 节肿胀, 且不良反应少安全性高。说明桂芍知母汤加味治疗本病标本兼治. 是治疗 早期类风湿性关节炎的有效方法。 关键词 早期类风湿关节炎、桂芍知母汤、中西医结合疗法 ABSTRACT Objective:Observe clinical curative effect of GuiShaoZhiMuthang to the early Rheumatoid arthritis. Method:As the breakthrough point in the influence of GuiShaoZhiMuthang add and subtract of Traditional Chinese Medicine on early Rheumatoid arthritis with these indexes of the patient symptom and physic sign,RF,ESR,CCP,CPR,dividing RA patients into two groups at random20cases of GuiShaoZhiMuthang with MTX,20 cases of Total Glucosides of Paeony Capsules with MTX. Result: Comparison of clinical efficacy :Treatment group the total effective rate was 94.3%，Significant efficiency 40%,The control group the total effective rate was 90.0%、Significant efficiency was 26.7%；Treatment group significant efficiency was better than The control group, The overall efficacy of the treatment group than the control group distribution Comparison of the main clinical symptoms : both group before and after treatment in patient symptom and physic sign, swollen pain, morning stiffness were significant effects , Treatment group significant efficiency was better than The control group In Laboratory of physical and chemical indicators :both groupe lower the RF、 ESR、CRP and CCP, Treatment group significant efficiency was better than The control group Side effect: The two groups before and after treatment showed no adverse reactions Conclusion:Clin