冠心通脉颗粒治疗冠心病心绞痛心血瘀阻证的临床研究-中药学专业论文.docxVIP

有统计学意义（P0.05），说明治疗组对总胆固醇降低程度优于对照组。治疗后两组 高密度脂蛋白比较，FAS 和 PPS 结果显示，治疗组组内比较均有统计学意义（P0.05）， 对照组无统计学意义。8、各组安全性分析结果：治疗结束后，两组均未发现与研究 药物有关的异常改变和其它不良反应。结论：冠心通脉颗粒能减轻冠心病心绞痛患者 的胸痛、胸闷、心悸不宁、唇色紫暗等临床症状，并能显著改善心绞痛持续时间、心 绞痛疼痛程度、发作时需要口含硝酸甘油的情况、含服硝酸甘油后缓解时间、硝酸甘 油用量等各项指征，同时也能改善患者的舌脉象，提示该药物对心血瘀阻证（冠心病 心绞痛）的治疗是比较显著的。对于心绞痛疗效以及部分症状、体征以及主要疗效性 指标上，冠心通脉颗粒明显优于对照组，在研究过程中未见明确的不良反应，临床用 药比较安全。 关键词：冠心通脉颗粒；冠心病；心绞痛；心血瘀阻证 Clinical Study on Treatment of Angina and Heart Blood Stasis Syndrome with Guanxin Tongmai Granules Abstract Coronary heart disease in today has become a serious threat to human health, clinical common diseases and frequently-occurring disease. In recent years, application of Traditional Chinese medicine prescription treatment of angina pectoris，clinical and experimental aspects of it made considerable progress. The issue on Guanxin Tongmai granules research on treatment of angina pectoris （Heart blood stasis syndrome）,clinical observation Guanxin Tongmai granules, so as to provide more effective clinical treatment. Objective: Through randomized controlled, multi-center clinical study, Guanxin Tongmai granules on the clinical efficacy and the clinical drug safety to make an objective clinical re-evaluation，Evaluation Guanxin Tongmai granules the clinical efficacy of treatment of angina pectoris, toxic side effects and adverse reactions. Methods: In accordance with research center for hierarchical, randomization and positive drug parallel control design testing. The test group patients taking Guanxin Tongmai granules, every time a bag, three times a day; The control group patients taking Jingzhi Guanxin granules, every time a bag, three times a day. Treatment for four weeks. Clinical evaluation criteria for: ECG、Angina、TCM、Individual symptoms or signs、Nitroglycerin reduced rate, etc. This study measured the number of indicators for both, standard deviation, minimum, maximum, median, interquartile range (IRQ), Measurement data t test; Comparison of two categories of indicators use fourfold