生物化学复习资料（全）-动态-warburge effect-3.pdfVIP

Seminars in Cell Developmental Biology 23 (2012) 352–361 Contents lists available at SciVerse ScienceDirect Seminars in Cell Developmental Biology j o u r na l h o me p a g e : w w w. elsev /locate/semcdb Review New aspects of the Warburg effect in cancer cell biology Steven J. Bensinger a,b,c,∗ , Heather R. Christofk b,c,d,e,∗ a Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA b Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA c Jonsson Comprehensive Cancer Center, UCLA, USA d Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA e Broad Stem Cell Research Center, UCLA, USA a r t i c l e i n f o a b s t r a c t Article history: Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic phenotype of Available online 8 March 2012 cancer is aerobic glycloysis – also known as the Warburg effect – characterized by increased metabolism of glucose to lactate in the presence of sufficient oxygen. Interest in the Warburg effect has escalated Keywords: in recent years due to the proven utility of FDG-PET for imaging tumors in cancer patients and growing Aerobic glycolysis evidence that mutations in oncogenes and