综述吸入制剂的研究进展.PDF

• 232 • 现代药物与临床 Drugs Clinic 第 28 卷 第 2 期 2013 年 3 月 • 综 述 • 吸入制剂的研究进展 1 2 2 2, 3 2* 王守斌 ，王 博 ，孙歆慧 ，王 维 ，任晓文 1. 天津市食品药品监督管理局 认证中心，天津 300191 2. 天津药物研究院 释药技术与药代动力学国家重点实验室，天津 300193 3. 天津中医药大学 研究生院，天津 300193 摘 要：吸入给药是防治哮喘、慢性阻塞性肺疾病等呼吸道疾病的首选给药方式。常见的吸入给药制剂包括压力定量吸入剂、 干粉吸入剂和雾化吸入剂。吸入给药有效的评价指标为粒径的测定，测定吸入制剂粒径的方法主要有撞击器法和光学仪器法。 就目前吸入给药制剂的优点、剂型分类、体外评价和研究现状等进行综述。 关键词：吸入给药；哮喘；慢性阻塞性肺疾病；体外评价 中图分类号：R944.7 文献标志码：A 文章编号：1674 - 5515(2013)02 - 0232 - 04 DOI: 10.7501/j.issn.1674-5515.2013.02.034 Research progress in inhalation preparation 1 2 2 2, 3 2 WANG Shou-bin , WANG Bo , SUN Xin-hui , WANG Wei , REN Xiao-wen 1. Certification Center of Tianjin Food and Drug Administration, Tianjin 300193, China 2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China 3. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract: Inhalation administration is the first choice for the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary diseases (COPD). In clinic, the most common used dosage forms for inhaled drug administration are pressurized metered-dose inhalation, dry powder inhalation, and atomizing inhalation. The in vitro effective evaluation index of inhalation is particle size, and the determination of particle size could be carried out with the impactors method and the optical instruments method. This review discusses the characteristic, classification, research status, and in vitro evaluation methods of inhalation preparation. Key words: inhalation a