干预肿瘤代谢的新策略氨基酸代谢的调控途径及其药物-药学学报.PDFVIP

药学学报 Acta Pharmaceutica Sinica 2019, 54(3): 407 −419 ·407 · 干预肿瘤代谢的新策略: 氨基酸代谢的调控途径及其药物研究进展 1 1 1 2 1 3* 1* 姜洪丽 , 蒋学阳 , 汤同中 , 柳文媛 , 冯 锋 , 孙昊鹏 , 曲 玮 ( 中国药科大学 1. 天然药物化学教研室, 2. 药物分析教研室, 3. 药物化学系, 江苏南京210000) 摘要: 肿瘤代谢重编程是肿瘤发生、发展过程中最关键的特征之一。许多癌症表现出对特定氨基酸的需求增 加, 或依赖于外源供应, 或调节氨基酸代谢途径, 导致相应氨基酸水平的改变以满足肿瘤发生发展的需要。因此, 如 能有效调节肿瘤依赖性氨基酸的水平, 可在细胞代谢的角度发展全新的肿瘤治疗策略。目前本领域已经取得了令 人瞩目的进展, 本文概述了与肿瘤发生发展密切相关的氨基酸代谢途径, 并对相应的调控机制及活性分子进行总 结, 最后就本领域的发展方向进行讨论与展望。 关键词: 氨基酸代谢; 肿瘤; 谷氨酰胺; 丝氨酸; 色氨酸; 代谢通路; 活性分子 中图分类号: R916 文献标识码: A 文章编号: 0513-4870(2019)03-0407-13 A new strategy to intervene tumor metabolism : regulatory targets for amino acid metabolism and advances in drug research 1 1 1 2 JIANG Hong-li , JIANG Xue-yang , TANG Tong-zhong , LIU Wen-yuan , FENG Feng1, SUN Hao-peng3*, QU Wei1* (1. School of Traditional Chinese Pharmacy, 2. Department of Pharmaceutical Analysis, 3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000, China) Abstract : Reprogramming of metabolism is one of the most critical features in tumorigenesis and tumor growth. Many types of cancer show an increased demand for specific amino acids, rely on exogenous supplies, or alter amino acid metabolic pathways, leading to changes in corresponding amino acid levels to meet the need of tumorigenesis. Therefore, if the level of tumor growth-dependent amino acids can be effectively controlled, a new treatment strategy can be developed from