乳腺癌钼靶X线征象与病理学预后因素的相关性研究.docVIP

乳腺癌钼靶X线征象与病理学预后因素的相关性研究 陈春华马小敏丁雅玲 （厦门市妇幼保健院放射科361003） 【摘要】目的:研宄乳腺癌钼靶X线征象与乳腺癌病理学预后因子的相关性。 方法：对420例乳腺癌患者术前行钼靶X线分析，术后病理测定肿瘤的组织学分 级、肿瘤的脉管浸润（LVI）、雌激素受体（ER）、孕激素受体（PR）、人类表皮生 长因子（Her-2）、肿瘤增殖指标（Ki-67）、抑癌基因P53的表达情况，对钼靶X 线征象与临床病理学预后因子的相关性采用单因素和多因素Logistic回归分析。 结果：钼靶X线征象中肿块伴随钙化，肿块边缘模糊与高组织学分级相关；肿块 伴随钙化，肿块边缘清晰与Ki-67阳性相关；单独钙化，肿块伴随钙化，大肿块 （〉5cm）与Her-2阳性相关；无影像征象与ER阳性、P53和LVI相关。结论： 乳腺癌部分钼靶X线征象与临床病理学预后因子有相关性，有一定的预测价值, 为乳腺癌的辅助治疗提供了 一定的信息。 【关键词】乳腺癌病理学预后因素钼靶X线 【中图分类号】R81 【文献标识码】A 【文章编号】2095-1752 （2014） 21-0274-03 Correlation Between the Mamographic Features and Prognostic Factors Abstract in Breast Cancer 【Abstract】 Objective The purpose of this study was to correlate mammographic findings with prognostic factors in patients with breast cancer. Methods Mammographic findings in 420 patients with breast cancers were retrospectively evaluated. Pathology reports relating to histological grade, lymphovascular invasion （LVI）, oestrogen receptor （ER） status, progesterone receptor （PR） status and Her-2/neu status ,P53 status,Ki-67 status were reviewed .Univariate and multivariate logistic regression was applied to analyze the association between mammographic findings and prognostic factors in patients with breast cancer. Results On mammography, Associated calcification were associated with many poor prognostic factors: high histological grade, positive Her-2 and Ki-67,Indistinct margins was associated with high histological grade,distinct margins were associated with positive Ki-67, calcifications alone、The sizes of masses（＞5cm） were associated with positive Her-2, None of finds was associated with positiveER、 P53 and LVI.Conclusion Several mammographic features can have a prognostic value in the subsequent treatment of patients with breast cancer. 【Keywords】 breast cancer cliniopathological markers mammography 乳腺癌的预后指标是?一个传统的研究课题。0前己知影响预后的因子奋多种， 比较公认的主要包括肿瘤临床分期、病理类型、组织学分级［1】。近年来，乳腺 癌生物学因子包括:雌激素受体（ER）、孕激素受体（PR）、人类表皮生长因子 （Her-2）、肿瘤增殖指标（Ki-67）、抑癌基因P53等在乳腺癌预后判断及疗效预 测中的价值引起了广泛的重视。生物学因子能很好地反映乳腺癌的生物学特征