帕瑞昔布钠在后路脊柱术后镇痛的疗效观察-南方医科大学学报.PDF

2010;30(6) 南方医科大学学报(JSouthMedUniv) 窑1323窑 帕瑞昔布钠在后路脊柱术后镇痛的疗效观察 1 1 2 1 2 1 2 蔡明雪 袁李雅兰 袁林宏生 袁彭雪梅 袁吴 昊 渊暨南大学附属第一医院 麻醉科袁 骨科袁广东 广州 510632冤 摘要院目的探讨帕瑞昔布钠在脊柱后路手术患者术后镇痛的临床疗效遥 方法全麻下行后路脊柱手术患者80例袁随机 分为帕瑞昔布钠组和安慰剂组袁双盲对照观察遥 镇痛方法院手术结束所有患者给予背景镇痛液吗啡 1.0mg/mL袁单次给 药剂量2ml后袁帕瑞昔布钠组渊40 例冤院静脉注射帕瑞昔布钠40mg袁安慰剂组渊40 例冤静脉注射生理盐水2ml曰术后24尧 48h予相同剂量重复给药遥观察VAS 疼痛评分尧患者满意度和不良反应遥结果与安慰剂组相比袁帕瑞昔布钠组术后6尧 12尧24尧48h 四个时间点VAS评分明显小于安慰机组渊P0.05冤遥两组满意率和不良反应发生率差异无统计学意义遥结论 脊柱后路术后短期应用帕瑞昔布钠镇痛袁可为患者提供良好的镇痛效果遥 关键词院帕瑞昔布钠曰脊柱后路术曰术后镇痛 中图分类号院R971.2 文献标识码院A 文章编号院1673-4254(2010)06-1323-02 Postoperativeanalgesiceffectofparecoxibsodiuminpatientswithposteriorspinalsurgery 1 1 2 1 2 CAIMing-xue,LIYa-lan ,LINHong-sheng,PENGXue-mei,WUHao 1 2 DepartmentofAnesthesiology, DepartmentofOrthopedics,FirstAffiliatedHospitalofJinanUniversity,Guangzhou510630,China Abstract: Objective Toinvestigatethepostoperativeanalgesiceffectofparecoxibsodiuminpatientswithposteriorspinal surgery. Methods Eightypatientsundergoingposteriorspinalsurgeryundergeneralanesthesiawererandomlydividedinto parecoxibsodiumgroupandplacebogroup(n=40).Allthepatientsreceivedasingledoseofmmlmorphine(1.0mg/ml)as the background analgesia immediately after the operation. The patients in parecoxi bsodium group were given 40 mg parecoxibsodiumintravenously,andthoseintheplacebogroupreceivedanequivalentvolumeofsalineinstead,andat24and 48haftertheoperation,thesamedosewasrepeated.Thevisualanalogpainscore,patientsatisfactionandadversereactions wererecordedaftertheadministrations. ResultsComparedwiththeplacebogroup, thepatientsinparecoxibsodiumgroup hadsignificantlyloweredVASscoreat6,12,24,and48haftertheoperation(P0.05).Nosignificantdifferenceswerenoted inthepatientsatisfactionandadversereactions