经皮雌激素课程实例.pptVIP

经皮吸收雌激素在绝经期激素治疗中的应用;潮热，盗汗 失眠 不规则或大量阴道出血 情绪波动，神经质 阴道萎缩、干燥 性交痛 骨质丢失，骨质疏松;HRT指征;HRT的适应症;2002年WHI CEE/MPA结果：总的相对风险和可归因风险;WHI研究：雌激素＋孕激素组;WHI研究：单纯雌激素组;心血管疾病的高危因素;血栓栓塞的风险在使用经皮雌激素或孕烷衍生物中不增加. ;非肠道途径雌激素;肝脏首过效应;肝脏首过效应;经皮补充雌激素; 对比口服雌激素经皮给药的卓越优势;经皮雌激素给药比口服给药更适合于下列人群;爱斯妥是什么;Algeria (1999), Argentina (1992), Austria (1997), Belgium (1978), Benin (1994), Brazil (1999/2005), Bulgaria (2002), Burkina Faso (1978), Cameroon (1995), Canada (1998), Cent African Republic (1997), China (1992), Colombia (2001), Congo (1991), Costa Rica (1997), Czech Republic (1997), Denmark (1994), Ecuador (2000), Egypt (1996), El Salvador (2001), Estonia (1995), Finland (1993), France (1974), Gabon (1997), Germany (1997), Greece (1999), Guatemala (2000), Guinea (1999), Honduras (2001), Hong Kong (1990), Hungary (1997), India (2003), Iceland (1997), Ireland (1994), Israel (1993), Italy (2000), Ivory Coast (1978), Lebanon, Lithuania (1996), Luxembourg (1980), Mali (1999), Mauritania (1997), Mexico (2001), Morocco (2000), Nigeria (1993), Portugal (1990), Madagascar (2004), Moldova (2004), Panama (2001), Peru (2000), Romania (1996), Russian Federation (1999), Senegal (1995), Singapore (1991), Slovakia (1995), South Africa (1996), South Korea (1992), Spain (1993), Sultana of Oman (1998), Switzerland (1986), Thailand (2002), Taiwan (1984), Togo (1997), Tunisia (1995), Ukraine (2000), United Kingdom (1998), United States (2004), Uruguay (1995), Venezuela (1993), Vietnam (2001), West Malaysia (1993), Zimbabwe (1995);纯天然雌二醇;;经皮吸收的途径;口服和经皮给药雌二醇的体内浓度;雌二醇给药途径对循环雌激素的影响;不同方案对脂质的影响（％）;;经皮给药可维持稳定的血药浓度;Scott RT Jr, et al. Obstet Gynecol. 1991;77:758–764;稳态血药浓度;药代动力学-与口服雌二醇比较;;爱斯妥雌二醇凝胶用法;使用注意;爱斯妥雌二醇凝胶用量;甲羟孕酮对代谢的影响;中国妇女长期使用爱斯妥?联合安琪坦?的临床观察;子宫内膜厚度的变化;阴道不规则???血程度;长期使用爱斯妥?联合安琪坦?的小结;HT-目前;虽然它们均是小汽车……. …….但它们的功率表现明显不同! 类似于不同HRT治疗方案!;HRT－ART;谢谢