供精人工授精临床妊娠相关影响因素分析.docVIP

供精人工授精临床妊娠相关影响因素分 析 梁云霞 张芳 郅洋 史雅萍 孔庆萍 刘雅丽 王莉莉 宋春英郭兴萍 山西省人口计生委科学研究所生殖中心 山西省人类 精子库 目的探讨影响供精人工授精(AID)临床妊娠率的多种因素。方法收集2010 年1月-2016年6月在山西省人口计生委科学研究所生殖屮心接受AID助孕治疗 的2 103个AID周期的临床资料，回顾性分析女方年龄、不孕类型、不孕年限 (年)、体质量指数、卵泡直径、子宫内膜厚度及分型、助孕方案、同一周期授 精次数等因素与周期临床妊娠率的关系。结果周期临床妊娠率为28. 4%o多因素 Logistic冋归分析显示，女方年龄、不孕类型与AID周期临床妊娠率有关 (P0. 05) o与〈30岁者比较，女方年龄305岁者接受AID治疗后妊娠失败的风 险是年龄〈30 岁者的 1.459 倍(OR=1. 459, 95%CI:1. 1351. 875, P0. 05),女方 年龄35岁者接受AID治疗后妊娠失败的风险是年龄〈30岁者的1. 524倍 (OR二1.524, 95%CI:1.3952. 150, P0. 05)。与原发不孕者比较，继发不孕者接 受AID治疗后妊娠失败的风险下降T 48. 4% (0R=0. 516, 95%CT:0. 333°. 798, P0. 05)。未发现其他因素与AID周期临床妊娠率有关。结论女方年龄越大，接 受AID治疗妊娠失败的风险越高;继发不孕者AID助孕失败的风险低于原发不孕 者。 关键词： 供精人工授精;临床妊娠;影响因素; 郭兴萍，E-ma订163. com :2017-02-16 基金：山西省卫牛计牛委科研项目(2015102) Analysis on related influencing factors of clinical pregnancy via artificial insemination by donor LIANG Yun-Xia ZHANG Fang ZHI Yang Reproductive Center, Population and Family Planning Scientific Institute of Shanxi Province; Abstract： Objective To explore the influencing factors of clinical pregnancy rate of artificial insemination by donor ( AID) . Methods The clinical data of 2 103 cycles of AID was collected in Reproductive Center of Population and Family Planning Scientific Tnstilute of Shanxi Province from January 2010 to June 2016. The relationships bet ween cycle clin ical pregna ncy reite and maternal age, type of infertility, years of infertility, body mass index ( BM1) , follicular diameter, endometrial thickness and type, assisted reproduction schedule, the number of insemination in the same cycle were an al yzed retrospectively. Resul Is The cycle clin ical preg nancy rate weis 28- 4%. Multivariate logistic regression analysis showed that maternal age and type of infertility were correlated with clinical pregnane)^ rate in AID cycle ( P0. 05) ? The risk of pregnancy failure after AID among the patients aged 30-35 years old was 0. 459 times more than that among the patients under 30 years old ( OR = 1. 459, 95% CI: 135-1. 875, P0.