生物资讯跟网路资源简介文档资料.pptVIP

生物資訊學的發展 生物資訊學的發展 涵蓋分子生物、資訊工程、統計等學門的新科學 後基因體分析紀元(Post-genome Era) 功能性基因體(Functional Genomics) ---基因註解 ---基因預測 ---蛋白質功能研究(proteomics) ---單核甘酸多樣性(single nucleotide polymorphisms or SNPs) Different technologies and resources into a proteomic process 資料庫的類型：依功能區分 原始資料庫 SMART - Simple Modular Architecture Research Tool NCBI 網路資源 vs. 套裝軟體 網路資源的優缺點 優點: - 資料庫更新頻繁 - 介面較易學習，操作容易 缺點: - 通常功能專一化 - 資料格式轉換不易 - 參數預設值無法調整 - 解讀輸出結果困難 網路資源 vs. 套裝軟體 套裝軟體的優缺點 優點: - 容易調整參數預設值 - 分析功能完整且具多樣化 - 資料格式統一，不同程式間不需轉換 - 可提供圖形檔輸出結果 缺點: - 資料庫更新較不頻繁 - 指令繁多不易學習 Bioinformatics Package Tools GCG - The Wisconsin Package – Accelrys Biocomputational Research GenoMax v3.3 – InforMax LSITM – Lion Bioscience Bioinformatics Package Tools LaserGene - DNAStar, Inc. MacVector - Oxford Molecular Group, Inc. Discovery Studio Gene - Oxford Molecular Group, Inc. Vector NTI - Informax, Inc. Literature, Bibliography and Reference Databases Medline MIM(Mendelian Inheritance in Man) Taxonomy Geneticode MIM(Mendelian Inheritance in Man) Browsing OMIM Nucleotide sequence databases EMBL/Genebank/DDBJ Containing every individually submitted primary sequence REFSEQ Provide non-redundant curated data representing knowledge of Known genes ENSEMBL annotated genomic contig sequence The International Nucleotide Sequence Database Collaboration (INSD) Genebank Protein sequence databases Swiss-Prot a curated protein sequence database which strives to provide a high level of annotation. SpTrEMBL a database supplementing the Swiss-Prot Protein Sequence Data Bank. TrEMBL contains the translations of all coding sequences (CDS) EMBL PIR identification and analysis of protein sequences and their corresponding coding sequences REFSEQP Protein information from REFSEQ SPTrEMBL Primary sequence could be further analysis……… Sequence database with analyzed annotation(special pattern found) Analysis tools Nucleotide related databases Special pattern of Nucleotide sequence REBASE Genome structure CPGISLAND, ENSEMBLCPG, LOC