解热镇痛抗炎药ANTIPYRETIC ANALGESIC ANDANTI-....pptxVIP

解热镇痛抗炎药ANTIPYRETIC ANALGESIC ANDANTI-INFLAMMATOGY DRUDS北京协和医学院基础医学院药理学系 叶菜英解热镇痛抗炎药antipyretic, analgesic, and antiinflammatory drugs These drugs relieve the pain associated with inflammation,including that from arthritis and gout.称为解热镇痛抗炎药（antipyretic, analgesic, and antiinflammatory drugs)。They produce their anti-inflammatory action through a different mechanism,not as glucocorticoid.1974年国际上将这类药物归入 非甾体类抗炎药类 （non-steroidal anti-inflammatordrugs,NSAIDs) 。解热镇痛抗炎药 解热作用 Antipyretil action hypothalamusantipyretic analgesic external feverendogenous pyrogen PL virusbacteriaBacterial productendotoxinTDAg-Abphagocyte （GC）inhibition unsaturated fatty acidPGS PG TEMP SET cellsfebrile 解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs解热作用 Antipyretil action Febrile:endogenous pyrogen →CNS →release PG↑ →thermotaxic center → FebrileAntipyretil ：inhibit PG synthetase，decrease synthesis of PG →hypothermy解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs 镇痛作用 analgesic action depression bradykinin pain sensorantipyretic analgesic painstimulus PG PG synthesis sensitization depression 解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs镇痛作用 analgesic action Mechanisms： Effect on periphery，inhibit the synthesis of prostaglandins and prevent bradykinin from stimulating pain receptors,also inhibit the recognition of pain impulses centrally and peripherally.解热镇痛抗炎药Antipyretic analgesic and anti –inflammatory drugs抗炎作用Anti-inflammatory action Mechanisms ：Inhibit a primary pathway in PG synthesis。Summary ：Inhibit the PG synthesis to antipyretil, analgesic and Anti-inflammatory Classification水杨酸 (Salicylates) 类： 阿司匹林aspirin等苯胺类 (Aniline)： 对乙酰氨基酚acetaminophen （扑热息痛）等吡唑酮 (Pyrazoketone) 类： 保泰松Phenylbutazone、羟基保泰松Oxyphenbutazone等芳基烷酸类：布洛芬brufen、炎痛喜康Piroxicam等 解热镇痛消炎药 水杨酸类 阿斯匹林 阿斯匹林 Aspirin水杨酸类Salicylates：阿司匹林 aspirin 【physiological disposition】：oral、absorbed from gut→distribution, metabolism→kenosis （enter articular cavity、CSF）阿司匹林 aspiri