乙醛酸法合成对羟基苯甲醛工艺研究.docVIP

乙醛酸法合成对羟基苯甲醛工艺研究 【摘要】本文研究了乙醛酸法合成对羟基苯甲醛的的制备工艺，包括对羟基扁桃酸的制备，对羟基扁桃酸氧化为对羟基苯甲醛工艺条件的探索等两个方面。在对羟基扁桃酸制备工艺中，当反应物摩尔比为苯酚：乙醛酸=2.5:1，反应温度50℃，反应时间7h，后处理pH=2时对羟基扁桃酸收率达81.4%。在氧化反应中，当催化剂摩尔比对羟基扁桃酸：五水合硫酸铜=1:2.5，反应时间为10h，反应温度为100℃，脱羧pH=2时对羟基苯甲醛收率达62.66%。 【关键词】对羟基扁桃酸；对羟基苯甲醛；氧化合成 注：本论文（设计）题目来源于教师的国家级（或省部级、厅级、市级、校级、企业）科研项目，项目编号为： 。 Synthesis of p-Hydroxybenzaldehyde by Glyoxylic acid Method [Abstract] The process of synthesis of p-Hydroxybenzaldehyde by glyoylic acid method was inversitgated in this dissertation, including the preparation of DL-4-Hydroxymandelic acid, the exploration of the oxidation process conditions and so on. In the preparation process of DL-4-Hydroxymandelic acid, when the molar ratio of reactants was phenol:glyoxylic acid=2.5:1, reaction temperature was 50°C, reaction time was 7h, post-treatment pH=2, the yield of DL-4-Hydroxymandelic acid was 81.4%. In the oxidation reaction, when the molar ratio of the catalyst to DL-4-Hydroxymandelic acid: Copper(II) sulfate pentahydrate =1:2.5, the reaction time is 10h, the reaction temperature is 100°C, and the decarboxylation pH=2, the yield of p-hydroxybenzaldehyde reaches 62.66%. [Keywords] DL-4-Hydroxymandelic acid p-Hydroxybenzaldehyde Oxidative synthesis PAGE \* MERGEFORMAT 22 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc508895841 1 前言 PAGEREF _Toc508895841 \h 1 HYPERLINK \l _Toc508895842 1.1 对羟基苯甲醛的性质和用途 PAGEREF _Toc508895842 \h 1 HYPERLINK \l _Toc508895843 1.2 对羟基苯甲醛的生产方法 PAGEREF _Toc508895843 \h 2 HYPERLINK \l _Toc508895844 1.2.1 苯酚法 PAGEREF _Toc508895844 \h 2 HYPERLINK \l _Toc508895845 1.2.2 对氨基苯甲醛法 PAGEREF _Toc508895845 \h 3 HYPERLINK \l _Toc508895846 1.2.3 对硝基甲苯法 PAGEREF _Toc508895846 \h 3 HYPERLINK \l _Toc508895847 1.2.4 对甲酚法 PAGEREF _Toc508895847 \h 4 HYPERLINK \l _Toc508895848 1.3 本课题研究的内容和目的 PAGEREF _Toc508895848 \h 4 HYPERLINK \l _Toc508895849 1.3.1 研究内容 PAGEREF _Toc508895849 \h 4 HYPERLINK \l _Toc508895850 1.3.2 研究目的 PAGEREF _Toc508895850 \h 5 HYPERLINK \l _Toc508895851 2 对