人工髋关节假体材料生物相容性及其临床应用.docVIP

人工髋关节假体材料生物相容性及其临床应用 中国组织工程研究与临床康复74誊34筋2010—08—20出版 JournalofClinicalRehabilitativeTissueEngineeringResearchAugust20,2010Vo1.14No.34 人工髋关节假体材料生物相容性及其临床应用★ 刘杨,杨威 Biocompatibilityandclinicalapplicationofhipprosthesismaterials LiuYang,YangWei Abstract OBJECTIVE:Toevaluatetheperf0rmanceofdifferenttypesofhipjointprosthesismaterials,aswellasbiocompatibilitywiththe hostafterimplantedvivo.toprovidereferenceforclinicalapplications METHODS:Using”hipjoint,prosthesis,materials,biocompatibility,clinicalapplication”inChineseandinEnglishasthekey wordsacomputerretrievalwasperformedforarticlespublishedbetweenJanuary2000andJuly2010.Articlesrelatedtothe biocompatibilityofbiologicalmaterialstothehostwereincluded,duplicatedresearchorMetaanalysiswereexcluded.Totally30 articlesfclcusedonthetype,performanceandclinicaIapplicationofhipreplacementprosthesismaterials. RESULTS:Mbinationofmetaljointheadandultra—highmolecular weightpolyethyleneacetabularisthemostwidelyusedinhipjointreplacement,butthereispoorresistancetoabrasion,poor lubrication,andpoorcorrosiveresistanceAsforceramic—typehipjointprosthesis,ceramicshaveastrongwearresistance,low toxicityandboneintegrationeffect,buttheirfragilitystillneedstosolve C0NCLUSION:The}deaIimplantmaterialsshouldhavegoodbiocompatibility,corrosionresistance,wearresistance,fatigue resistance.strongstrengthandelasticmodulusclosertothecharacteristicsofhumancorticalbone,whichneedtobefurther developed LiuY,YangW.BiocompatibilityandclinicalapplicationofhipprosthesismaterialsZhongguoZuzhiGongchengYanjiuyu LinchuangKangfu2010:14(34):6441—6444.[http://www.crter.ca】 摘要 目的:评价不同种类髋关节假体材料的性能以及置入体内与宿主的生物相容性,为其在l临床上的应用提供参考依据. 方法:以”髋关节,假体,材料.生物相容性,临床应用”为中文关键词,以”hipjoint,prosthesis,materials,biocompatibility, clinicalapplication”为英文关键词,采用计算机检索2000—01/2010—07相关文章.纳入与有关生物材料与宿主生物相容性 的文章,排除重复研究或Meta分析类文章.以30篇文献为重点,探讨髋关节黄换假体材料的种类,性能及临床应用. 结果:金属材料在人工髋关节假体中占有重要的地位,髋关节置换应用最多的是金属关节头和超高分子量聚乙烯髋臼的组 合,但存在耐磨损性差,润滑性差的缺点,且抗腐蚀性较差.陶瓷对陶瓷类型的人工髋关节假体材料,具有很强的抗磨损 性能和较小的毒性作用及骨整合作用,但是其易碎性仍足需要解决的问题. 结论