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人GLP-1类似物利拉鲁肽 开启2型糖尿病治疗新篇章 改善β细胞功能,延缓疾病进展 强效控制血糖,低血糖发生少 减轻体重,改善代谢 降低收缩压,减少心血管危险因素 Thank you! * ANIMATED SLIDE The unmet need in type 2 diabetes Progression of type 2 diabetes is characterised by a decline in beta-cell function and deterioration of glycaemic control. These issues persist despite a large oral antidiabetic armamentarium for the management of patients with type 2 diabetes, and an abundance of treatment guidelines. In fact, currently available treatments can increase risk of weight gain and hypoglycaemia; weight gain can increase the risk of CVD. The development of new treatments may bring us closer to reversing this situation and provide clinicians with the ‘ideal’ antidiabetic therapy. Outcome - 43% of patients do not achieve glycaemic targets The study by Ford et al. aimed to examine trends in glycaemic control among US adults with diagnosed diabetes from 1999 to 2004. Data from The National Health and Nutrition Examination Survey (NHANES) 1999–2004 showed that 43% of diabetes patients aged 20 years+ were found to have HbA1c levels above 7%. The results from the study by Ford et al. are consistent with other data suggesting that improvements in glycaemic control have occurred among patients with diabetes in the US. The authors suggest that “as welcome as the recent favorable trends in glycaemic control are, additional efforts are needed to help the 40% of patients with diabetes who do not have adequate glycaemic control.” Reference Ford et al. (NHANES). Diabetes Care. 2008; 31: 102–4. * * ANIMATED SLIDE Beta-cell function has fallen by 50% at diagnosis. References: DeFronzo RA. From the triumvirate to the ominous octet – a new paradigm for the treatment of T2DM. The Banting Lecture. Presented at: American Diabetes Association 68th Scientific Sessions; June 6-10, 2008; San Francisco. Also: DeFronzo R, Banerji M, Bray G, Buchanan T, Clement S, Henry R, Kitabchi A, Mudaliar S, Musi N, Ratner R, Reaven P, Schwenke D, Tr
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