中氮茚萘醌类化合物与CT-DNA相互作用的电化学-南京师范大学学报.PDF

30 1 () V ol. 30 No. 1 2007 3 JOU RNAL OF NAN JING NORM AL UN IV ERSITY ( N atural Sc ience Edition) M ar, 2007 中氮茚萘醌类化合物与 CT-DNA 相互 作用的电化学 李 静, 杜江燕, 王炳祥, 龚美娟, 罗 鹏 ( , 2 10097 ) [] 4 DNA ( CT-DNA ) ( G C ) . , pH 712 PBS , ; CT-DNA , CT-DNA . [] , CT-DNA, , [ ] O 64 6 [] A [ ] 100 1-4 616( 2007) 01-0064-04 Interaction Between Indolizine-Naphthoquinones and CT-DNA by Cyclic Voltamm etry L i J ing, D u J iangyan, W ang B ingx iang, Gong Me ijuan, L uo Peng ( S chool o Ch em istry and Environm ental S cience, N anjing N orm al U n ivers ity, N anjing 2 10097, C h ina) Abstract: The inte raction o our indo lizine-naphthoquinones and CT-DNA w as stud ied by cy clic vo ltam- m etry at g lass carbon e lectrode. T he results ind ica ted that there w e re wt o couples o redox peaks and the redox reaction w as contro lled m a inly by di u sion rom the curve o I vs scan rate. T he currents and peaks p o indo lizine-naphthoqu inones decreased and shi ted to the positive d irection by adding CT-DNA in pH = 71 2 PBS so lu tion. It can be suggested tha t the inte raction be wt een indo lizine- naph thoquinones and DNA m ay be in the interca la tive mode in the pH = 71 2 phospha te bu e r solution. K ey words: indo lizine-naphthoqu inones, CT-DNA, interaction, e lec trochem ica l action 引言 , ,