ffr 临床应用 课件.ppt

* * * * Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessmentCatheterization and Cardiovascular Interventions, October 2006.Joshua J. Fischer, MD 1, Xin-Qun Wang, MS 1 2, Habib Samady, MD 1, Ian J. Sarembock, MD 1, Eric R. Powers, MD 1, Lawrence W. Gimple, MD 1, Michael Ragosta, MD 1 *1The Cardiovascular Division, Department of Medicine, University of Virginia Health Systems, Charlottesville, Virginia2Department of Health Evaluation Sciences, University of Virginia Health Systems, Charlottesville, Virginiaemail: Michael Ragosta (mragosta@virginia.edu)*Correspondence to Michael Ragosta, Interventional Cardiology, Box 800158, University of Virginia Health Systems, Charlottesville, VA 22908, USA AbstractObjectives: To determine the outcome of consecutive patients with and without acute coronary syndromes (ACS) in whom revascularization was deferred on the basis of fractional flow reserve (FFR). Background: FFR 0.75 correlates with ischemia on noninvasive tests and deferral of treatment on the basis of FFR is associated with low event rates in selected populations. Whether these low event rates apply to patients undergoing assessment of moderate stenoses in association with an ACS is not known and is an important clinical question. Methods: Retrospective analysis and 12 month follow-up of consecutive, moderate (50-70%) de novo coronary lesions assessed with FFR. Results: Revascularization was deferred in 120 lesions (111 patients) with FFR 0.75. ACS was present in 35 patients (40 lesions). The clinical, angiographic and coronary hemodynamic characteristics of patients with and without ACS were similar. Among the 35 patients with ACS, there were 3 deaths, 1 MI, and 6 target vessel revascularizations (TVRs) (15% of lesions). Among the 76 patients without ACS, there were 5 deaths, 1 MI, and 7 TVRs (9% of lesions). Conclusions: Deferral of revasculariz