T cell激活.pptVIP

Polyclonal stimuli for lymphocytes name isolated from category target concanavalin A Jack bean lectin T cells (刀豆素A，Con A） phytohaemagglutinin kidney bean lectin T cells (植物血凝素, PHA） pokeweed mitogen pokeweed lectin T/B cells (美洲商陆, PWM） lipopolysaccharide G- bacteria endotoxin B cells * (脂多糖, LPS） superantigen G+ bacteria enterotoxin T cells # (超抗原, sAg） * in mouse # some for B cells 0 50 100 150 200 250 0 0.5 1 2 3 4 Intermingled skin grafting (week) IL-10 concentration (pg/ml) serum local tissue IL-10 concentrations in sera and the local tissues in rat model with the intermingled skin transplantation Activation and maturation of CD8 CTL Th0 CD8 CTL-p Th1 CD4 T CD8 CTL-p CTL APC target cell target cell IL-12 CTL target cell APC IL-2 non-professional APC cytolysis The memory T cells chapter eight T Cell Activation 6 When an antigen is encountered more than once, the adaptive immune response to each subsequent encounter is speedier and more effective, a crucial feature of protective immunity known as immunological memory. Memory cells are lymphocytes that mediate immunological memory. Memory cells are specific for a particular antigen and are long-lived. 记忆性T细胞的发育 记忆性T细胞的发育经历扩增、收缩和记忆三个时相，并依赖于抗原刺激。抗原刺激的强度 以持续时间表示（左侧黑色部分）。只有最适强度抗原的激发才能产生一群能够自我复制 并行使回忆反应的抗原特异性记忆性T细胞。 免疫记忆 功效 表面标志 定居部位 TEM 保护性记忆 速发性效应 CD45RO+ 外周炎症组织 CD27-CCR7+ CD62L- TCM 中枢