面向基因预测的信息处理方法研究-计算机应用技术专业毕业论文.docxVIP

博士学位论文：面向基因预测的信息处理方法研究遗传算法在保持个体多样性方面存在的不足，引入了生物免疫应答机制和网络调 博士学位论文：面向基因预测的信息处理方法研究 遗传算法在保持个体多样性方面存在的不足，引入了生物免疫应答机制和网络调 节机制，提出了一种用于基因5’exons预测的免疫遗传算法。该算法利用T细胞 发育过程中强大的多样性维持机制来设计算法的选择机制，按免疫网络调节机制 实现其动态平衡，提高了算法的求解性能。 (4)在分析了现有基因预测研究工作的基础上，运用统计组合思想将多种 基因从头预测方法综合起来进行基因5’exons预测，提出了一种基于统计组合的 基因5’exorls预测算法，利用不同基因预测程序的基因注释结果来进行分析组合， 该算法较好地将HMM、IGA、QDA等多种信息处理方法综合在一起进行基因预 测。 本论文应用信息处理方法对基因5’exons区域预测进行了研究，提出了相应 的基因预测算法并构建了基因预测模型，不仅具有重要的理论价值和广阔的应用 前景，而且对于相关交叉学科的发展也具有重要的意义。 关键词：生物信息学；基因预测；5’exons；免疫遗传算法；统计组合 II AbstractAbstract Abstract Abstract The tremendOUS interest in bioinformatics．a new discipline at the intersection of molecular biology,computer science and mathematic，is fueled by the excitement surrounding the sequcnecing of the human genome and the promise of a new era in which genomic research dramatically improves the human condition．Gene prediction iS a vital research field in bioinformatics．And the prediction of the 5’exons iS the key and essential point in gene prediction，whose research result not only has great significance in establishing a complete gene prediction mode，but also guides the research of gene expression，gene control，gene functional prediction and biomedical engineering． Tbjs dissertation focuses on problems existing in the prediction of 5’exons and explores gene areas especially the signal characteristics in 5’exons area by combining and adopting some biological theories and statistic methods to extract the sequence characteristics modes reflecting the features in this area and make predictions of gene sequence by classifying．At the same time，according to the goals and characterisitics of the issues in predicting 5’exons area,a relatively effective gene predicting algorithm is designed and a gene prediction model is constructed which is based on the statistical combination and the feature classification that improves the predicting precision of of gene characteristics，gene-prediction and integratice prediction．111e main research work of this dissert