没食子酸烷基酯合成工艺研究-有机化学专业毕业论文.docxVIP

AbstractGallic Abstract Gallic acid alkyl esters possess strong antioxidant and antibacterial activity,which were widely utilized in food，medicine，cosmetic and feed industry etc．Based on this，studies on reaction rules，process conditions， separation and purification method of products with respect to the synthesis of methyl gallate似G)，dodecyl gallate(DG)and gallic acid stearyl ester(SG)v／a Fischer esterification were implemented，and the synthesis method of electronic grade methyl gallate was preliminarily discussed as well in this paper．The main content are as following： (1)In the study of synthesis of MG the resin and sulfuric acid were used as catalysts．The rule of esterification reaction using resin as catalyst were explored，and also Thermodynamic characteristics and kinetic characteristics of the reaction were analyzed．Through orthogonal experiments，the ratio of acid to alcohol，the amount of sulfuric acid and reaction time were investigated．The optimal conditions of esterification： industrial grade gallic acid 0．05 mol，methanol 50 mL，catalyst amount 0．6 mL，reflux reaction time 1 2 h，the yield of product was more than 95％．In addition，a preliminary study on the synthesis of electronic grade MG was carded out． (2)In the study of synthesis of DG selection of suitable catalyst， water-carrying agent and solvent were implemented through single factor III 万方数据 experiment．Besides，through experiment．Besides，through orthogonal experiment，the optimal process parameters were obtained：industrial grade gallic acid 2．0 mol，lauryl alcohol 2．4 mol，solvent amount 500 mL，catalyst amount 20 g，reaction time 1 2-1 6 h under oil bath heating and stirring condition．The esterification rate was 97％．In addition，separation of the reaction product and purification of the crude ester were carried out．Isolation，recyle and analysis method of raw material and solvent were preliminarily investigated； (3)In the study of synthesis of SG；the preliminary conditions of the reaction were investigat