活性氧与糖基化终产物致动脉粥样硬化作用的关系.pdf

中国病理生理杂志 　Chinese Journal of Pathophysiology 　2003 ,19 ( 12) :1705 - 1708 ·1705 · ( ) [文章编号] 　1000 - 4718 2003 12 - 1705 - 04 活性氧与糖基化终产物致动脉粥样 硬化作用的关系 冯 　 , 　刘乃丰 (东南大学心血管病研究所/ 附属中大医院心内科 , 江苏 南京 210009) Interaction of reactive oxygen species in atherogenetic properties of advanced glycation end products in diabetes FEN GJie , L IU Nai - feng ( Institute f or Cardiovascular Diseases , Dep artment of Cardiology of Zhongda Hosp ital , Southeast University , N anj ing 2 10009 , China) ( ) 　　【A Revie w】　There is overwhelming evidence for an involvement of reactive oxygen species ROS in the ( ) ( ) pathogenesis of atherosclerosis AS in diabetes mellitus DM . For many years , knowledge on the contribution ( ) to diabetic complications and vascular disease induced by advanced glycation end - products A GEs has been rising. During the development of atherosclerosis , A GEs and ROS might have interaction . In this article , we provided four angles of view to discuss the role of ROS in the pathogenesis of atherosclerosis : the chemistry of ROS , the effect of vascular targets of ROS on activity of A GEs , the role of ROS in the pathogenesis of athero genesis by A GEs , the same effect of ROS and A GEs - transcriptional regulation . 　　[ 关键词] 　活性氧 ; 动脉硬化 ; 糖尿病 　　[ KEY WORDS] 　Reactive oxygen species ; Arteriosclerosis ; Diabetes mellitus 　　[