绝经后妇女血清白细胞介素-17和雌二醇与牙周炎的相关性研究-口腔临床医学专业毕业论文.docxVIP

Ab Abstract PAGE PAGE IV ABSTRACT Objetive: The purpose of this investigation was to analyze by cross-sectional design the association between serum Interleukin-17(IL-17) and estradiol(E2) status and periodontitis in postmenopausal women,to discuss the alteration and the meaning of Interleukin-17 and estradiol occurred in patients with the evolve chronic periodontitis,and provide treatment reference that IL-17 as a target and estrogen replacement therapy for periodontitis in postmenopausal women . Methods ： We recruited accordanced with thediagnostic criteria and inclusion criteria for the study, including 32 patients with chronic periodontitis ((including 12 E2-defieient subjects and 20 E2 -suffieient subjects) and 32 healthy controls,all within 7 years after menopause,Venous blood 5ml, and the serum of each women was separated.Clinical measurements were recorded.Enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of IL-17 in serum ， Electrochemilu minescence immunoassay (ECL）was used to detect the levels of estradiol in serum. Results ： 1 、 The concentration of IL-17 in serum with CP was 49.64±9.30pg/ml；The concentration of IL-17 in serum with in healthy persons was 19.88±7.36pg/ml,which was significant lower than that of the CP. Positive correlation was found between IL-17 level and clinical measurements(PD,AL and BI).The correlation coefficient were 0.383,(p=0.031)；0.522,(p=0.002)；0.594,(p=0.000). 2、The concentration of estradiol in serum with CP is 24.06±12.26pg/ml；The concentration of estradiol in serum with in healthy persons is 26.87± 12.57pg/ml,05) ． No significant diffirence was found between the concentration of estradiol in serum with CP and healthy persons.Date dindicated that PD and BI were not different between E2- dificient and E2-sufficient subjects. E2- dificient peridontitis subjects had a high AL . 3 、 Date dindicated that the concentration of IL-17 in serum were different betwe