抗菌中药及其有效成分的热动力学研究-化学 物理化学专业毕业论文.docxVIP

微量量热法用于中草药对细茵的代谢作用的研究是一种新的手 微量量热法用于中草药对细茵的代谢作用的研究是一种新的手 段，首先它能直接监测生物体所固有的热力学过程；其次，可直接监 测微生物的组织和悬浮液；其三，热测量完毕之后，并没有破坏研究 体系，还可以补充必要的后继分析。它不仅能提供热力学数据，而且 可以提供动力学的信息。因此成为一种很有前途的研究手段，比抑菌 圜法、光谱法更加方便可靠。 2．2研究体系新 近年来对中药的研究多集中于某一种成分的活性研究，用量热法 在中药及其有效成分对细菌的抑制作用上研究较少，缺少系统性。本 文把中药及其活性成分作为研究体系，最终得到药物对大肠杆菌生长 代谢的规律，为药物的开发和应用提供了理论基础。 2．3与生命科学相关的中药振荡的探索 对于中药非平衡非线性现象报道很少。本文把中药参与的振荡体 系作为研究对象，探索药物与人体生命活动的关系，为治疗疾病，科 学合理的使用中药提供信息。 AbstractThe Abstract The Chinese natural drugs play an important role in traditional medicine， which ale one of the important weapons to cure diseases．111cy have powerful vital force and wide developmental future．The study of activity of natural drugs and the exploitation of new drugs by high-tech attract much attention of more and more scientists． In this paper the bacteriostasic activity of four kinds of drugs including their effective components were studied by microcalorimetry．Using 2277 Thermal Activity Monitor,the power-time curves were determined and analyzed，and then the theoretical model and thermodynamic equation of bacterium growth were constructed．In addition BZ oscillating reaction of these drugs was studied in order to get more thermodynamic parameters．All ofthe above provide theoretical basis for syntheses ofnew medicine and reasonable usage ofnatural drugs． 1．The chief contents 1．1The extraction ofdrugs According to the methods in references，the effective components of drugs were extracted in suitable ways(e．g．distillation method，extraction，exchange process et a1．)． 1．2 The study of the regulation by which the E．coli．grows and metabolizes in culture medium containing drugs of different concentration In order to find the regulation of the metabolization of E．coli．and the optimum concentration of drugs，drugs of different concentrations were put into the liquid culture medium containing E．coli．to get suspending liquid．The power-time curves of E．coli．at 3 1 0K were analyzed using Logistic equation SO that the growth rate constant of E．coli．in drugs o