虎杖苷的降尿酸作用及其机制研究Anti-hyperuricemia-药学学报.PDF

虎杖苷的降尿酸作用及其机制研究Anti-hyperuricemia-药学学报.PDF

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药学学报 Acta Pharmaceutica Sinica 20 14, 49 ( 12): 1739 1742 ·1739 · · 究简报· 虎杖苷的降尿酸作用及其机制研究 1 2* 1 杲 , 吴汉斌 , 蒋 红 (1. 解放军第4 11 医院, 上海 200081; 2. 同济大学附属东方医院, 上海 200120) 关键词: 虎杖苷; 高尿酸血症; 尿酸转运体蛋白1; 阴离子转运蛋白 中图分类号: R285 文献标识码: A 文章编号: 0513-4870 (20 14) 12- 1739-04 Anti-hyperuricemia effect and mechanism of polydatin in mice 1 2* 1 WU Gao , WU Han-bin , JIANG Hong (1. The 411 Hospi tal of PLA, Shanghai 200081, China; 2. Shanghai East Hosp ital Affi liated to Tongji University, Shanghai 200120, China ) Abstract : Hyperuricemia mice model was established with uricase inhibitor (potassium oxonate) and uric 1 1 acids in serum were observed. Polydatin (5, 10, 20 mg ·kg ) and benzbromarone (16.7 mg ·kg ) were given ig for 7 d in mice. Kidney tissues were used to detect gene contents of urate anion transporter 1 (URAT 1), organic anion transporter 1 (OAT 1) and organic anion transporter 3 (OAT3) by real-time-PCR. The results showed that polydatin and benzbromarone can significantly reduce uric acid in blood of hyperuricemia mice ( P 0.05), compared with the model group. URAT 1, OAT 1 and OAT3 contents of the kidney in hyperuricemia mice changed significantly (P 0.05), compared with the blank group. Polydatin can significantly inhibit the changing trends in these genes induced by potassium oxonate in a dose-d

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