脉通方对自发性糖尿病大鼠动脉内皮细胞及相关因素的影响-中医内科学专业毕业论文.docxVIP

成都中医药人学ABSTRACT 成都中医药人学 ABSTRACT objective：To investigate the effect of Maitongfang on blood vessel endothelial cell ofGK rats． Methods：The GK rats are spontaneous diabetic rat models．The rats were randomly divided into four groups， ie．m曲dosage of Maitongfang，low dosage of Maitongfang， and Cilostazol group，Model control，Then dealed with preconcerted project，The effect of different medicines on the following parameters were detected by radioimmunoassay， biochemistry detect method， Histomorphometry，elc．which were level of seYIlm insulin， blood glueose，vegf， 1L-6pathologic artery．Generic fettle． Results：Three months later，the level of blood glucose of Cilostazol group and Model control was remarkable higher than High dosage of Maitongfang and low dosage of Maitongfang(p0．05、O．01)；the level of senlm insulin of High dosage of Maitongfang was remarkable difference from Cilostazol group p0．011；the level of VEGF of High dosage of Maitongfang and low dosage of Maitongfang was difference from Cilostazol group and Model control(p0．01)，and Cilostazol group was remarkable difference from Model control；the level of IL-6 of Hi曲dosage of Maitongfang and low dosage of Maitongfang was difference from Model control(p(0．01)， and Cilostazol group was remarkable difference from Model control(p0．05)；The average proportion of absent blood vessel endothelial cell of Model control contrast to High dosage of Maitongfang pO，01，Hi曲dosage of Maitongfang contrast to Cilostazol group p0．05． Conclusion：Hiigh dosage of Maitongfang demonstrates the action of improving the general condition，adjustingthemetabolism ofblood glucose，insulin，VEGF and IL-6， correcting the dysfunction of endothelium，The comprehensive curative effect of Maitongfang is superior to that of Cilostazol group． Key words： Maitongfang VEGF IL-6 GK rats Macrovascular disease S 成都中医药大学日U 成都中医药大学 日U 舌 据1997年WHO预测，21世纪2型糖尿病将在发展中国家流行，预计到2025 年全世界糖尿病患者将达到3亿 。我国目前2型糖尿病患病率为3．22％，占总 体发病率的90％以上。我国2型糖尿病和代谢综合征以及相关疾病的发生也呈 上升趋势，我国城市20岁以