抗膜联蛋白V抗体与反复自然流产的关系探讨-妇产科学专业毕业论文.docxVIP

硕士学位论文 硕士学位论文 中文摘要 续阳性者成功率0．00％，二者比较有差异(P0．05)。 结论： 1、aANX—IgG抗体与早期反复自然流产密切相关，且浓度不受 妊娠影响，有助于预测流产结局。 2、aANX-IgG抗体导致血浆粘度升高，并影响13一hCG分泌，是 其导致自然流产的发病机制。 3、aANX-IgM抗体与早期反复自然流产无关。 关键词：抗膜联蛋白V抗体，反复自然流产，免疫性流产，13 -hCG，血浆粘度 Ⅱ 硕士学位论文 硕士学位论文 英文摘要 Objects,To investigate the relationship between anti-annexin V antibodies and recurrent spontaneous abortion． Methods：The serum samples，which we坞曲tained from the study group，composed of 73 women with early recurrent spontaneous abortion (27 unpregnant women and 46 early pregnant women)，and from the control group，composed of 42 normal women(20 unpregnant women and 22 early pregnant women)，were measured by Enzyme-Linked immunosorbant assay for anti-annexin V IgG and IgM antibodies．Human ehorionic gonadotropin(B-hCG)of pregnant women Was measured by Mieropartiele Enzyme Immunoassay．Plasma viscosity Was measured by automatic-hemorheologie machine． Results： (1)The study group demonstrated significantly higher concentration of anti-annexin V IgG than the control group口O．01)，no difference of concentration of anti—annexin V IgG Was demonstrated between pregnant and unpregnant women口0．05)，the positive ratio of anti-annexin V IgG of the study group is 21．92％，higher than that of the control group(PO．05)，but no difference of concentration of anti—annexin V IgM was seen between the study and control group(P-)o．05)． (2)The plasma viscosity of the study group with positive anti—annexin V IgG Was higher than that of the study group with negative anti-annexin V IgG(PO．05)。and Was significantly higher than that of the control group口0．01)．The plasma viscosity of the study group with negative anti-annexin V IgG Was also higher than that of the control group(P0I．05)． (3)皿e upgrading ratio of B-hCG every other day in the study group with positive anti-annexin V IgG Was lower than that of the study group with negative anti—annexin V IgG(PO．05)，and significantly lower than that of the control group口o．oi)．The upgrading ratio of B -hCG every other day in the s