汕头大学医学院药理学精品课程 Antipyretic-analgesic and antiinflammatory drugs.pptVIP

Antipyretic-analgesic and antiinflammatory drugs Department of Pharmacology Zhang Yan-mei Non-steroidal anti-inflammatory drugs (NSAIDs) NSAIDs have three major actions, all of which are due mainly to the inhibition of arachidonic acid cyclo-oxygenase in inflammatory cells (the COX-2 isoenzyme), and the resultant decrease in prostanoid synthesis. Non-steroidal anti-inflammatory drugs (NSAIDs) An anti-inflammatory action: The decrease in vasodilator prostaglandins (PGE2, PGI2) means less vasodilatation and, indirectly, less oedema. The inhibition of activity of adhesion molecule. (3) Accu