上海交通大学临床血液学课件　cytogenetics AP ECHO.pptVIP

STI571/As4S4对CML协同靶向治疗: BCR-ABL融合蛋白和异常酪氨酸激酶作为靶点 15 der(17) 17 der(15) Tg mice Long latency:12m low penetrance: 20-30% 急性早幼粒细胞白血病(APL)-多步骤发病 原理和靶向治疗 急性早幼粒细胞白血病(APL)-多步骤发病原理和靶向治疗 急性早幼粒细胞白血病(APL)-多步骤发病原理和 靶向治疗 Tg mice with both PML-RARa and FLT3 mutation have early onset disease in most animals (number) (57) (42) (5) (104) 2 17 (40.5%) 2 21 (20.2%) * 50 6 (5.8%) 77 (74.0%) 24 104 FLT3 mutation in only part of APL cases and its disappearance ahead of PML-RARa over remission suggests it as an event after PML-RARa 急性早幼粒细胞白血病(APL)-多步骤发病原理和 靶向治疗 Paradigm shift: f