精神分裂症静息态脑功能整合研究.docVIP

第四军医大学硕士学位论文 Study of resting state brain function integration in schizophrenia Candidate for master: Chang Xiao Supervisor: Miao Danmin School of Medical Psychology, Fourth Military Medical University, Xi‘an, 710032, China Abstract With the rapid development of socioeconomy, people’s living standards have largely been improved. Yet, the state of mental health is emerging as a hidden threat to individual’s living qualities and to the stability of the whole society. Schizophrenia is the most affected severe mental illness, making 1% of the total population worldwide live with sufferings. The most vulnerable period of being attacked by the disease is from adolescent to young adults. Patients have low cure rate but high relapse likelihood, leaving many patients rely on medications throughout their lives. Schizophrenia is damage to sufferers’ cognitive functions and social adaptabilities. The ability loss can hardly be fully recovered, leading to a high disability rate among patients. Moreover, the ubiquity of prejudice and discrimination against mental illness makes patients and their families live in the shadow of shame and embarrassment. Too often, they have to fight with the unbearable pressure and heavy financial burden at the same time. The insights of biological psychiatry make people realize that schizophrenia is part of a biological problem with central nervous system lesions. Early brain imaging studies have discovered that patients have ventricle enlargement, brain volume decrease and gray matter / white matter atrophy in many areas. The widespread neuropathological changes -6- 第四军医大学硕士学位论文 and the complex behavior symptoms cannot be explained by focal brain injuries. Instead, researchers came up with the “dysconnectivity hypothesis” of schizophrenia, which facilitated a better understanding of the extensive local aberrances and the core pathological symptoms from a perspective of functional integration. Mounting evidence supported this theory. Functional int