胃癌中Smac、MDM2的表达与幽门螺杆菌L型感染的研究.doc

related with the age and sex (P0.05). 2)RT-PCR results showed that the amount of MDM2 mRNA expressed in the gastric cancer tissues was significantly higher than that expressed in the normal control group (P 0.05) and the expression level was related with infiltration depth、lymph node metastasis、degree of differentiation (P 0.05), not related with the age and sex(P0.05). (3)Hp - L test results : the gram stain: 100 cases of gastric cancer tissues detected Hp - L positive rate was 79.0% (79/100), Use IHC detected Hp - L positive detection rate was % (76/100), the testing results of the two methods are consistent (P 0.05); So 70 cases of Hp-L positive in 100 cases of gastric cancer tissue,(define gram stain L detection and detected with immunohistochemical staining positive Hp-L was) at the same time, the positive rate was 70.0%. 2) control group 19 cases of gram staining detected Hp-L, positive rate was 47.5% (19/40). IHC detection,17 cases Hp-L positive detection rate was % (17/40), also has consistency with gram stainings (P 0.05). 40 cases of control group in the Hp-L checked out in 13, detection rate was 32.5% (13/40), visible in gastric cancer group and positive rate of Hp-L was obviously higher than that of control group, the difference is statistically significant (P 0.05); After statistics analysis in gastric cancer group Hp-L just associated with the lymph node metastasis of gastric cancer (P ); not related with the the size of the lump in gastric cancer, cancer cell differentiation degree, infiltration depth and TNM staging, associated with patients age and gender is not (P 0.05). (4)In gastric cancer group , The correlation analysis showed that there was negative correlation between the protein of Smac and MDM2 .( r=-0.429,P0.05) (5) In gastric carcinoma the Smac protein positive rate was25.00% in the group that Hp-L form was positive and it was lower than that in the group in which the Hp-L form was negative.And the infection of Hp-L form was negati