整合蛋白内化及再循环机制-中国细胞生物学学报.PDFVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(9): 1228– 1233 DOI: 10.11844/cj cb.2017.09.0089 整合蛋白内化及再循环机制 张鲁馨 张 欣 王继红* (辽宁师范大学生命科学学院, 大连10165) 摘要 整合蛋白是一类异源二聚体跨膜受体, 通过介导细胞与细胞、细胞与细胞外基质以 及细胞与病原体间的相互作用, 影响细胞增殖、迁移、分化和凋亡, 因此在癌症等疾病发生过程中 具有重要的作用。整合蛋白的构象和活性决定了其与配体的结合能力, 这种结合能力对整合蛋白 功能的调控起到至关重要的作用。研究发现, 某些整合蛋白能持续地从细胞表面内化形成内体, 随 后再循环到细胞表面, 这个过程主要通过快速(短环路)和缓慢(长环路) 两种循环途径完成。以上表 明, 整合蛋白的内化和再循环途径受到时间和空间上的调控。该综述阐述了整合蛋白内化的分子 机制和再循环路径。 关键词 整合蛋白; 内化; 再循环路径 The Mechanism of Intergrin Internalization and Recycling Zhang Luxin, Zhang Xin, Wang Jihong* (College of Life Sciences, Liaoning Normal University, Dalian 10165, China) Abstract Integrins are heterodimeric transmembrane receptors implicated in cell proliferation, migration, differentiation and apotosis by mediating the interaction of cells with cells, extracellular matrix (ECM) and pathogens, and play an important role in the progression of diseases like cancer. The ablility of integrin binding with ligands depends on its conformation and activity, which plays a key role in the regulation of integrin function. Many studies have found that certain intergrin heterodimers are continuously internalized from the plasma membrane into endosomal compartments and subsequently recycled back to the cell surface. This process is mainly through fast (short-loop) and slow (long-loop) pathways to complete recycle. It indicates a tempo-spatial regulation for the integrin internalization and recycling pathways. This review elucidates the molecular mechanisms and recycling pathways of integrin internalization. Keywords integrin; internalization; recycling pathways α 整合蛋白是一类异源二聚体跨膜受体, 由 和