药师：林育成培训课件.pptVIP

* * * * * * 1 dose = 0.5 ml * * * DTaP-Hib :combination and associated的比較,D, T, P的免疫效果不會被Aluminum compounds干擾 但Hib的免疫效力會被Aluminum compounds干擾降低 (33-92%) DTaP-HB : no significant interaction of each other. DTaP-IPV : avoid the known interaction of IPV with thiomersal, DTaP antigens were preserved in 2-phenoxyethanol. * * PHARMACEUTICAL ASPECTS OF COMBINATION VACCINES Reduce immune response : DTaP-Hib---reduce Hib immune response, DTwP-IPV---reduce P , measles vaccines + meningococcal polysaccharide type a and c results in reduced seroconversion for both vaccines. Overload : However, it is generally accepted that it will be crucial in formulating new combination vaccines to ensure that the load of distinct antigens does not exceed the capacity of the presentation system. * DTaP-Hib :combination and associated的比較,D, T, P的免疫效果不會被干擾 但Hib的免疫效力降低 (33-92%) DTaP-HB : no significant interaction of each other. DTaP-IPV : avoid the known interaction of IPV with thiomersal, DTaP antigens were preserved in 2-phenoxyethanol. * * * Mechanical mixing : genes encoding proteins into a suitable vector such as a naturally or artificially attenuated virus or becterium. * * * * Clinical programs of combination vaccine 1.Safety 2.Efficacy equivalent 3.Consistency of the immune response 4.Compatibility with other vaccines given at the same time. * Compatibility Component : live attenuated vaccines preservatives : avoid the known interaction of IPV with thiomersal, DTaP antigens were preserved in 2-phenoxyethanol. adjuvent : e.g, the ratio of aluminum hydroxide and aluminum phosphate, pH , buffer Toxicology Immunological interaction Reduce immune response : Antigenic overload : at what point antigenic overload will be crucial in formulating is not known. Antibody subclass response : total IgG response COMBINATION VACCINES * Effect of Combinations Based on Acellular Pertussis Vaccines on the Immunogenicity of Individual Antigens * The effect of combination on future vac