临产前后子宫平滑肌及胎膜ETA、EGFR的变化及其与母血、羊水中E,2、P的相关关系-妇产科学专业论文.docxVIP

望些堡塞!堕主煎亘至宣兰塑墼：堕堕占旦兰：!Q!墨塑壅些壁皇堡塑：芏查±12：!箜差墨 望些堡塞!堕主煎亘至宣兰塑墼：堕堕占旦兰：!Q!墨塑壅些壁皇堡塑：芏查±12：!箜差墨 ! h 3．494 1832．25)pmol／L(P0．05)，羊水中，临产前E2浓度为(5112． 94±173176)pmol／L，临产后为(10727．14+2031．87)pmol／L，升高 更为明显(P0．01)。(3)临产后子宫平滑肌细胞、胎膜细胞上ETA、 EGFR表达较临产前增强，两组阳性细胞率及吸光度A值比较，有显 著差异性(P0．05)。在胎膜组织上，ETA主要在合体滋养细胞上表 达，在间质中有少量表达；EGFR主要在合体滋养细胞上表达，间质 中有少量表达。(4)子宫平滑肌细胞、胎膜细胞上ETA、EGFR表达 的变化与羊水、母血中E2呈显著正相关，而与孕激素无关。 结论：E2、ETA、EGFR在临产后浓度增加；E2可能具有刺激予 ， 宫平滑肌细胞、胎膜细胞上ETA、EGFR合成增加的作用，而孕激素 可能不具备这种作用。 关键词： 内皮素 表皮生长因子．尿抑胃素 子宫平滑肌 胎膜 分娩发动 毕业论文：临产前后子宫平滑肌、胎膜上ETA、EGFR艘套化建皇堡塑!苎查±垦：呈堕羞墨The 毕业论文：临产前后子宫平滑肌、胎膜上ETA、EGFR艘套化建皇堡塑!苎查±垦：呈堕羞墨 The Changes in Expression of EGFR、ETA in Myometrium and Fetal Membrane and Their Relationships with E2、P in Maternal Serum and Amniotic Fluid Before and After the Onset of Labor Abstract objective：1 To study the’changes of estradiol、progesterone in maternal seruln and amniotic fluid，epidermal growth factor receptor(EGFR)、endothalin receptor A(ETA)on myometrium and fetal membrane in the initiation of human parturition．2 To investigate the correlation between EGFR、ETA and estradiol、progestoren during the course of labor． Methods：Seventy gravida women were divided into two groups．One group are thirty-three women who were at term labor but delivered by cesarean for failed labor progression，the other group are thirty—seven women who arc at term not-in-labor．Both groups were drawn the myome仃ium、fetal membrane and arnniotic fluid during the course of cesarean．Matemal blood were obtained before cesarean．1 EGFR、ETA were determined by means of immunohistochemcal SABC t method and computer quantitative image analysis．2 The concentrations of estradiol、progestoren were measured by radioimmunoassay． Results：1 The concentrations of estradiol in matemal serum and amniotic fluid were significantly higher after the onset of labor[(9342．224-1401．42)pmol／L，(10727．14：／：2031．87)pmol／L，resepectively] than those before the onset labor[(6733．494-1832．25)pmol／L,(5112．944-1731．76) pmol／L。P