厄他培南对控制院内耐药环境的价值.ppt

* * * * * * * * * * * * * IVZ 2008-W-1259216-SS MS* In the current era of multidrug resistance, antibiotic stewardship—adequate and responsible antibiotic use—is essential. Specifically, clinicians must attempt to choose antimicrobial agents that are effective against target organisms yet have a low propensity for resistance.1 There are several challenges to antibiotic stewardship in this era of highly prevalent multidrug-resistant gram-negative organisms. Extended-spectrum β-lactamases (ESBLs), which are resistant to cephalosporins, fluoroquinolones, trimethoprim, and aminoglycosides, are no