聚碳酸亚丙酯PPC乳液的制备与性能研究.DOC

Effects of emulsifier and continuous phase on the biodegradable poly(propylene carbonate) emulsion Li-sha Pan1* , Chen-man Wang1, Jiacheng Li1, Nai Xu1, Tao Wang2* 1. Institute of Materials and Chemical Engineering, Hainan University, Haikou 570228, Hainan, China 2. Faculty of Medical and Human Sciences, The University of Manchester, Manchester M13 9GE, United Kingdom *Corresponding author: Lisha Pan, Tel: +86-0898 E-mail: happylisap@163.com Tao Wang, Tel:+44-(0)1612751508; E-mail: Tao.Wang@manchester.ac.uk Abstract: Poly(propylene carbonate) (PPC)is a novel biodegradable material. PPC has great potential to be used not only in the cosmetic chemical industry, but also in the medical material industry due to its good biodegradability and biocompatibility. One of the advantages of making PPC emulsion is that PPC could reduce the amount of organic solvent required as compared to the traditional solvent blending method, thus using PPC emulsion has emerged as a novel technique for preparing PPC materials. The amount and hydrophilic-lipophilic balance (HLB) value of emulsifiers along with the content of continuous phase determine the properties, such as appearance, stability, solid content, conductivity, and particle size, of the PPC emulsion. The effect of different parameters on the properties of the resulting PPC emulsion was investigated. With chloroform as the dispersion phase solvent and 1 wt% of aqueous polyvinyl alcohol (PVA) solution as the continuous phase, a relatively stable white-opaque with pan blue light emitting PPC emulsion was obtained by stirring the mixture for 1 h at room temperature where 2.5 wt% of emulsifier with a HLB value 13.0 was used. However, emulsions prepared with HLB value in the range of 12.6–16.0 except for HLB 13.0 failed to exhibit good performance. Decreased stability of the resulting PPC emulsion was noted at PVA concentrations higher than 1.0 wt%. Moreover, we also found an increase in the production of solid con