心肌梗死后抑郁患者血脂水平的研究.docVIP

心肌梗死后抑郁患者血脂水平的研究 永州市第三人民医院心内科湖南永州425000 目的观察冠心病(CHD)心肌梗死(Ml)后抑郁患者血脂 水平变化。方法 对78例Ml后患者分别采用抑郁自评量表(SDS)和汉密尔顿 抑郁量表(HAMD)进行评定，符合Ml后抑郁诊断的37例患者为抑郁症组， Ml后无抑郁状态的41例患者为对照组，检测血脂水平，并与40例健康体检者 进行比较。结果抑郁症组血清胆?固醇(TC)水平低于对照组和正常对照组(P 〈0.05),对照组TC水平高于正常对照组(P 0.05)o 3组血清甘油三酯(TG)、 高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL?C)水平差异均无统计学意义(P〉 0.05)o结论 血清TC水平可作为Ml后抑郁患者诊治的实验室参考依据。 关键词冠心病；心肌梗死；抑郁症；血脂 Abstract 0bjective To observe the changes of serum lipid concentration in patients with post-myocardial infarction (Ml) depression.Methods 37 diagnosed depression patients were chosed as depression group, 41 patients without depression as control group, who were assessed by Self-Rating Depression Scale (SDS) and Hamilton depression rating scale (HAMD), and 40 healthy controls were chosed as normal control group, Compared the changes in serum lipid concentration among those.Results The serum concentration of total cholesterol (TC) in depression group was ingnificantly lower than those in control group and normal control group (P lt; 0.05), and the serum TC concentration in control group was higher than normal control group (P 0.05) .The serum concentrations of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) had showed no significant differences among those three groups (P gt; 0.05). Conclusions The serum TC concentration could be used as diagnosis and treatment of laboratory basis in patients with post-MI depression. Key words] Cor on ary heart disease； Myocardial inf arcti on； Depressi on； Serum lipid concentration 冠心病(coronary heart disease, CHD)是临床上常见的心血管疾病， 而心肌梗死(myocardial infarction Ml)是CHD中最严重的类型。目前抑郁症是 世界上第三人疾病。近年来CHD合并抑郁症的患者越来越多，而抑郁症也影响 CHD患者的预后，增加患者心脏性事件的发生和病死率，二者的关系越来越受到 人们的关注和重视。有研究表明血脂水平异常与抑郁有关［1］。本研究对Ml后抑 郁患者与血脂异常的关系进行初步探讨，现报道如下。 1资料与方法 1.1 一般资料选自我院2008年3月至2014年3月收治心内科的 Ml患者78例，均符合2001年中华医学会心血管病学分会、中华心血管病杂志 编委会委员会和中国循环杂志编辑委员会依据大量循证医学的临床实验结果，参 考美国心脏病学院和美国心脏协会(ACC/AHA) 1999年修订的Ml治疗指南，并 结合我国具体情况，制订的Ml诊断标准。符合美国精神障碍诊断和统计手册第 4版(DSM-IV)和中国