哌替啶的药理作用与作用(精).pptVIP

Chapter 19 Analgesics objective 1. 掌握 吗啡、哌替啶的药理作用与作用 机制、临床应用,不良反应和禁忌症。 2. 熟悉 阿片生物碱类镇痛药的概念、分类 可待因、喷他佐辛、曲马朵、 罗通定、纳洛酮的药理作用和临床用途. 3.了解 其他镇痛药的概念与应用特点 Introduction pain 【definition】 1) a common experience; 2) an essential defensive function, 3) an unpleasant sensory and emotion 4) with actual or potential tissue damage . Opioid analgesics Pharmacokinetics  First-pass elimination is extensive bioavailability is low. Passes through BBB and placenta（胎盘）barrier. Excretes ： kidn