4.窦京涛-黎明现象的思考.pptVIP

IGFBP-1可以结合IGF-1，使游离的IGF-1水平下降，血糖水平升高。实际上IGFBP-3是结合IGF-1的主要分子，但是两者的结合量相对恒定，所以IGFBP-1是调节游离的IGF-1水平的主要分子。 IGF-1可以负向调节GH，使GH分泌量减少，血糖水平降低。 胰岛素可以负向调节IGFBP-1.胰岛素不足时，IGFBP-1水平升高，使游离的IGF-1水平下降，血糖水平升高。 * Summary OBJECTIVE lnsulln resistance increases durlng adolescence, and is exaggerated in patients with insulin dependent diabetes mellitus (IDDM). A relatlve deficiency of insulin-like growth factor-I (IGF-I) may contrlbute to this increased insulin requirement. Two mechanisms have been proposed: (a) increased GH secretion, caused by failure of IGF feedback control, leading to increased insulin resist