探讨抗病毒药物治疗乙肝后肝硬化的临床效果.docVIP

探讨抗病毒药物治疗乙肝后肝硬化的临床效果 黑龙江省嫩江县伊拉哈镇中心卫牛院161437 目的研究分析抗病毒药物治疗乙肝后肝硬化的临床效果。方法此次 研究的对象是选择在我院住院治疗的乙肝后肝硬化患者86例，将其临床资料进 行回顾性分析，并随机分为两组，两组均在常规护肝及对症治疗的同时给予抗病 毒方案治疗，其中，对照组43例给予恩替卡韦抗病毒药物，观察组43例给予阿 德福韦抗病毒药物，硏究并分析两种抗病毒治疗乙肝后肝硬化的临床效果。结果 通过对两组临床治疗效果的比较发现，对照组治疗总有效率为93.02%,观察组 治疗总有效率95.35%,两组之间比较差异无统计学意义(Pgt;0.05)；两组在用 药期间均有个别患者出现恶心、食欲下降、乏力、慢性腹泻、腹胀等不良反应现 象，但均能耐受，在持续用药和适当干预后症状消失或缓解。两组患者不良反应 发牛率比较差异无统计学意义(Pgt;0.05)o结论恩替卡韦或是阿德福韦抗病毒 药物，对治疗乙肝后肝硬化均有非常显著的疗效，均属于较为理想的抗病毒药物。 关键词抗病毒药物；乙肝后肝硬化；临床疗效 [Abstract] Objective To study the clinical effect of antiviral drugs in the treatment of hepatitis B patients with cirrhosis. The object of this research method is selected in the 86 cases of liver cirrhosis patients with hepatitis B in our hospital, the clinical data were retrospectively analyzed, and randomly divided into two groups, two groups were in routine and symptomatic treatment given antiviral treatment, among them, 43 cases in control group were give n en tecavir resista nee virus drugs, 43 cases in observation group were given adefovir antiviral drugs, research and clinical analysis of two types of antiviral treatment of hepatitis B cirrhosis? Results by comparing the clinical therapeutic effect of two groups, the control group total effective rate was 93.02%, the total efficiency of the observation group 95.35%, the differenee between the two groups was not statistically significant (Pgt;0.05)； the two groups during the treatment of individual patients with adverse reaction of nausea, loss of appetite, fatigue, chronic diarrhea, abdominal distension so, but can be tolerated in continuous medication and appropriate intervention symptoms disappeared or alleviated. There was no sign 讦 icant d iff ere nee in the in cide nee of adverse reactions between the two groups (Pgt;0.05) . Conclusion entecavir or adefovir antiviral drugs for treatment of liver cirrhosis after hepatitis B treatment were very significant, are ideal antiviral drugs. Antiviral drugs； hepatitis B cirrhosis； clinical effect 乙肝主