探讨联合检测糖化血红蛋白和胱抑素C对糖尿病早期肾功能损害的诊断价值.docVIP

探讨联合检测糖化血红蛋白和胱抑素C对糖尿病早期肾功能 损害的诊断价值 （成都军区八一骨科医院检验科 四川成都610031） 目的:探讨联合检测糖化血红蛋白和胱抑素C对糖尿病早期肾功能 损害的诊断价值。方法:随机选择2015年4月?2016年5月间确诊为2型糖尿病 的患者90例作为研究组对象，分为单纯糖尿病组45例和早期糖尿病肾病组45 例，同期选择45例健康人作为对照组，分别检测糖化血红蛋白和胱抑素C的浓 度水平，综合分析结果。结果:早期糖冰病肾组的糖化血红蛋口和胱抑素C浓度 水平均明显高于单纯糖尿病组和健康对照组，差异具有统计学意义（PV0.05）。 早期糖尿病肾组患者的糖化血红蛋白浓度水平与胱抑素C浓度水平呈正相关（r 值为0.8092, PV0.05）。早期糖尿病肾组患者联合检测糖化血红蛋口和胱抑素C 的阳性检出率明显高于单独指标的检测结果，差异均具有统计学意义（P0.05）, 并高于单纯糖尿病组患者的联合阳性检出率，差异具有统计学意义（PV0.05）。 结论:糖化血红蛋口和胱抑素C均是辅助诊断糖尿病早期肾功能损害的有效指标, 联合检测能够有效提高疾病的检出率，降低漏诊风险。 关键词 糖尿病；糖尿病肾病；糖化血红蛋胱抑素C R44 A 1007-8231 （2016） 26-0147-02 To explore the diag no Stic value of the early diabetic renal damage by the combined detection of glycosylated hemoglobin and cystatin C Jian Jie, Dong Dagao, Zhong Yiming, Zhou Lan, Zhao Min. The Laboratory Medici ne of the Bayi orthopaedics hospital of Che ng Du military area, Sichua n, China, 610031 Abstract] Objective To explore the diag no Stic value of the early diabetic renal damage by the combined detection of glycosylated hemoglobin and cystatin C. Methods Choosing 90 cases of patients with diabetic disease for the experimental group, 45 cases of patients were the simple diabetes group and the others were the experimental group, and 45 cases healthy check-up for the control group, testing the glycosylated hemoglobin and cystatin C, analyze the results comprehensively. Results There were sign讦icantly higher of the experimental group of the glycosylated hemoglobin and cystatin C results than the simple diabetes group and healthy control group(Plt;0.05). Related to early diabetic renal patients with glycated hemoglobin levels and cystatin C levels were positively (r=0.8092, Plt;0.05). There were sign讦icantly higher of the experimental group of the positive detection rate by the combined detection of glycosylated hemoglobin and cystatin C results than the results of individual indicator(Plt;0.05), and also higher than the simple diabetes group (Plt;0.05) ? ConclusionThere both are effective indicators