来曲唑与氯米芬促排卵治疗多囊卵巢综合征的疗效比较.docVIP

来曲卩坐与氯米芬促排卵治疗多囊卵巢综合征的疗效比较 徐州市妇幼保健院妇科江苏徐州221009 【摘 要】目的：观察来曲哇与氯米芬促排卵治疗多囊卵巢综合征 (PCOS)的临床疗效比较。方法：选择2013年6月?2015年6月在我院治疗的 多囊卵巢综合征(PCOS)的患者62例，随机分为两组，每组各31例，分别给 予来曲哇和氯米芬治疗，比较两组患者的排卵率、妊娠率、子宫内膜厚度，成熟 卵泡数等指标进行分析。结果：两组患者的排卵率及妊娠率相似，但氯米芬组成 熟卵泡数高于来曲哇组，而HCG日子宫内膜厚度及OHSS发生率低于来曲哇组, 差异具有统计学意义(PV0.05)。结论：来曲卩坐应用于多囊卵巢综合征不孕患者 促排卵治疗中，可以减少多胎妊娠和OHSS发牛率，对子宫内膜容受性影响小, 更有利于胚胎着床，具临床推广价值。 【关键词】来曲哇；氯米芬；促排卵治疗；多囊卵巢综合征(PCOS) Abstract Objective： To compare the observed letrozole and clomiphene citrate ovulation induction treatment of polycystic ovary syndrome (PCOS) clinical efficacy.Methods： 62 patients in our hospital with polycystic ovary syndrome (PCOS) from June 2015 to June 2013 were randomly divided into two groups, each of the 31 cases were treated with letrozole and clomiphene citrate.The ovulation rate, pregnancy rate, endometrial thickness，and the number of mature follicles in the two groups were compared.Results： The ovulation rate and pregnancy rate in the two groups were similar, but the number of mature follicles in the clomiphene citrate group is higher than the letrozole group, while the endometrial thickness on the day of hCG in jecti on and OHSS rate is lower tha n the letrozole group, the d iff ere nee was statistically significance (Plt;0.05) .Conclusion： Letrozole application in PCOS in fertility patients to promote ovulati on treatment, can reduce the in cidence of multiple pregnancy and OHSS, little effect on endometrial receptivity, more conducive to embryo implantation, so it has clinical value. Key words： Letrozole； Clomiphene citrate； Ovulation induction therapy； Polycystic ovary syndrome (PCOS) 多囊卵巢综合症(polycystic ovarian syndrome, PCOS)是以稀发排卵或 无排卵、高雄激素或胰岛素抵抗、多囊卵巢为特征的内分泌紊乱的症候群。PCOS 是妇科较常见的内分泌紊乱性疾病，发病率约占育龄妇女的4%-12%,约有 55%?75%的PCOS患者的不孕与排卵障碍有关，90%以上患者合并有排卵障碍, 是女性无排卵不孕常见病之一［1］。目前促排卵治疗是帮助PCOS不孕患者的常用 手段。氯米芬(clomiphene citrate, CC)是临床常用的促排卵药物。因其价格低 廉，应用方便，目前在国内临床上作为-?线促排卵药物使用，但是约有20%-25% 的患者在临床上对CC不敏感，并存在多胎妊娠、妊娠率低、流产率高等缺陷的 风险。 近年来研究发现，来曲畔(Letrozole, LET)被应用PCOS不孕患者促排 卵的治疗中，可以诱发卵泡