某院623例药品不良反应报告分析.docVIP

某院623例药品不良反应报告分析 黄月莹高欣涛刘弘 解放军152医院药学部 摘要： 目的了解某院药品不良反应（ADR）发牛的一般规律及特点，为临床合理用药 提供参考。方法 采用回顾性分析方法，对某院2011-01-01—2015-12-31收集的 623例填报完整和有分析评价的ADR报告进行分析。结果ADR发生的男、女比例 为0. 99 ： 1;静脉滴注引发ADR的比例最高（8 43%）;涉及药品种类以抗微生物 药最多（39.97%） ;ADR累及器官或系统最多的是皮肤及其附件（44.66%）、全 身性损害（21.96%）等。结论医院应积极、规范地开展ADR监测和上报工作，提 高患者的用药安全;药学部门要加大ADR知识的培训，提高医护人员的重视度和 积极性。 关键词: 药品不良反应;回顾性分析;监测; 收稿日期:2017-02-22 Analysis on 623 case s reports with adverse drug reaction in a hospital of PLA HUANG Yue-ying GAO Xin-Tao LIU Hong Department of Pharmacy, No. 152 Central of PLA; Abstract： Objective To investigate the feature and regularity of adverse drug reactions (ADRs) occurred in author s hospital so as to provide a reference for rational medication in clinic. Methods All the 623 cases of ADRs collected in the hospital from January 1, 2011 to December 31, 2015 which were reported completely and had obtained analysis evaluation were analyzed retrospectively. Results Among the 623 ADRs cases, the male to female was 0. 99 ： 1，the highest perce nt age bel on ged to in travenous drip was 88. 43%. The emtimicrobial drug was the most drug varieties involved (39. 37%) . The most common involved organs/systeins of ADRs were skin and appendages disorders (44.66%) , followed by systemic lesions (21. 96%) ? Conclusion The monitoring and reporting ADRs should be carried on positively and normatively in hospitai so that to improve the security of using drugs. Pharmacy department should rcinforcc the training of ADRs knowledge to improve the attention and motivation of the medical staff. Keyword： Adverse drug reaction; Retrospective analysis; Monitor; Received： 2017-02-22 药品不良反应(adverse drug reaction, ADR)是指合格药品在正常用法用量下 出现的与用药目的无关或意外的有害反应HL ADR存在巨大的安全隐患，与医 疗质量及医疗安全息息相关。通过对笔者所在医院5年来收集的623例ADR报告 进行整理、统计、分析，进一步了解和掌握ADR的一般规律和特点，为临床合理 用药提供依据，对减少ADR的发牛率起到积极的作用。 1资料与方法 通过“药品不良反应监测系统”收集笔者所在医院2011-01-01-2015-12-31由 科室I矢师和护士上报的ADRs报告，共623例，并对患者性别与年龄、涉及药品 种类、给药途径、ADRs累及器官或系统及ADRs转归等进行了分析 2结果 2.1报告人职业分布情况 按照报告人职业统计，2011年一2015年笔者所在|矢院623例A