雷帕霉素通过调控mTOR信号通路及SIRT水平增加雌性大鼠的卵泡储备和延长卵巢寿命-妇产科学专业论文.docxVIP

汕头大 汕头大学医学院硕士学位论文 汕头 汕头大学医学院硕士学位论文 PAGE PAGE III PAGE PAGE IV ABSTRACT Objective: The aim of the study is to learn about the effects of rapamycin on ovarian follicle development and investigate the role of mTOR signaling pathway and sirtuin. Maerials and Methods: 16 mature female SD rats were randomly divided into the following groups: the control group and the rapamycin-treated group. Rapamycin was dissolved in a vehicle containing 5.2% Tween-80 and 5.2% polyethylene glycol 400. All the rats were treated with an every other day’s intraperitoneal injection of rapamycin (for the rapamycin