七年制双语绪论 基础 核医学仪器.ppt

PET tracers Decays by emitting a positron A short life Chemically combined with a metabolically active molecule A waiting period 11C,13N,15O,18F PET Isotopes Nuclide T1/2 Production Carbon-11 20.4 min 10B(d,n)11C Nitrogen-13 9.96 min 12C(d,n)13N Oxygen-15 2.05 min 14N(d,n)15O 16O(p,pn)15O 12C(a,n)15O Fluorine-18 110 min 18O(p,n)18F Copper-64 12.7 hrs 64Ni(p,n)64Cu PET Image fusion technique To correlate the relativly coarse PET images to high-resolution anatomic images acquired by MR imageing or CT is called image fusion. Image fusion technique Image fusion technique Image fusion technique CT-PET PET Brain Metabolism Imaging CT - PET fusion PET-MRI Imaging Fusion Nonimaging instrument Uptake Probe γ Well Counter Dose Calibrator Survey Meter Thyroid uptake system Well Counter/ Uptake Probe Used to “count” disintegrations given off by radiopharmaceutical in patient or in test tubes Unit of disintegrations disintegrations per time (dps) counts per minute (cpm) γ Well Counter A γwell counter is a NaI (Tl) detector that has been specially designed to maximize efficiency. A channel (or well) is made in the center of the crystal.With this design, the source can be placed in the well so that high geometric efficiency is obtained. γ Well Counter Dose Calibrator The dose calibrator is an ionization chamber that allows assay of gamma emitters. Dose Calibrator Assay radioactivity in radiopharmaceutical Readout in units of Curie microCurie : uCi milliCurie: mCi Dose Calibrator Survey Meter Used to detect radiation exposure readings Readout in units of exposure Roentgen per hour: R/hr Any Questions? * * It is a kidney scan * Ti is a Hepatobiliary Scintigraphy, to diagnosis the biliary obstruction, use vary little tracer. * * * * * Compton effect Energy range：Several to 0.5MeV Part energy give orbital electrons Residual energy give scattered photon Incidence γ Compton e- scatteringγ Elastic collision K L M Electron pair prod