纳米医学与动脉粥样硬化防治-第三军医大学学报.doc

PAGE PAGE 8 动脉粥样硬化防治纳米医学 张建祥 400038 重庆，第三军医大学；药学院药剂学教研室暨药物研究所 Nanomedicine in atherosclerosis management Abstract Cardiovascular disease (CVD) is one of the most important diseases threatening the human health worldwide. Atherosclerosis (AS) is the common pathological change of a broad spectrum of lethal CVDs such as myocardial infarction and stroke. Pharmaceutical treatment based on early diagnosis of vulnerable plaques is the most effective strategy for the management of AS. Unfortunately, precise diagnosis and effective therapy of AS by traditional reagents have been largely limited due to critical issues such as low resolution/sensitivity, low drug concentration at diseased sites, and severe side effects. Rapid development in nanomedicine has offered great promising for the targeted therapy of AS. This review summarizes the state-of-the-art achievements on nanosystems for molecular imaging and targeted therapy of AS. Future development in this field was also discussed. Key words: nanomedicine; atherosclerosis; molecular imaging; targeted therapy 过去的半个多世纪，尽管公共卫生、临床心脏病学和新的治疗药物的发现使得心血管疾病的死亡率逐渐下降，全球范围内依然有30%的死亡由心血管疾病导致，超过包括癌症在内的其他所有疾病 ADDIN EN.CITE EndNoteCiteAuthorSwirski/AuthorYear2013/YearRecNum51/RecNumrecordrec-number51/rec-numberref-type name=Journal Article17/ref-typecontributorsauthorsauthorSwirski, F.K./authorauthorNahrendorf, M./author/authors/contributorstitlestitleLeukocyte behavior in atherosclerosis, myocardial infarction, and heart failure/titlesecondary-titleScience/secondary-title/titlespages161-166/pagesvolume339/volumedatesyear2013/year/datesurls/urls/record/Cite/EndNote[1]。动脉粥样硬化（atherosclerosis, AS）是冠状动脉疾病、颈动脉疾病、外周血管疾病和中风等心脑血管疾病的共同病理改变 ADDIN EN.CITE EndNoteCiteAuthorFalk/AuthorYear2006/YearRecNum16/RecNumrecordrec-number16/rec-numberref-type name=Journal Article17/ref-typecontributorsauthorsauthorFalk, E./author/authors/contributorstitlestitlePathogenesis of atherosclerosis/titlesecondary-titleJ. Am. Coll. Cardiol./secondary-title/titlespage