【药师之友】左氧氟沙星与头孢西丁治疗成人非重症社区获得性肺炎的成本--效果分析.docVIP

【药师之友】左氧氟沙星与头孢西丁治疗成人非重症社区获得性肺炎的成本- 效果分析 作者：刘思婧.（德阳市第二人民医院药剂科，四川德阳618000）目的：评价左氧氟沙星与头孢西丁治疗成人非重症社区获得性肺炎（CAP）的成本-效果。方法：选取71 例成人非重症CAP住院患者，按照使用抗菌药物的不同分成左氧氟沙星组（A组）33 例和头孢西丁组（B组）38 例。A组患者静脉滴注甲磺酸左氧氟沙星注射液200 ml，每日1 次；B组患者静脉滴注注射用头孢西丁钠2.0 g，每日3 次。疗程均为8 d。观察两组患者的临床疗效、显效时间、不良反应，并进行成本-效果分析。结果：A组和B组患者的总有效率分别为87.88％和65.79％，显效时间分别为（5.53±2.56）d 和（3.87±3.03）d，差异均有统计学意义（P＜0.05）；两组患者不良反应发生率比较，差异无统计学意义（χ2＝0.47，P＞0.05）。A组和B组方案的总成本分别为6 748.93 元和8 110.34 元，成本-效果比分别为76.80 和123.28，增量成本-效果比为－61.63％。敏感度分析结果与成本-效果分析结果一致。结论：左氧氟沙星治疗成人非重症CAP更为经济。 Cost-effectiveness Analysis of Levofloxacin and Cefoxitin in the Treatmentof Adult Non-severe Community-acquired PneumoniaLIU Si-jing（Dept.of Pharmacy，Deyang Second People’s Hospital，Sichuan Deyang 618000，China）ABSTRACT OBJECTIVE：Toevaluate and compare cost-effectiveness of levofloxacin and cefoxitin in thetreatment of adultnon-severecommunity-acquired pneumonia（CAP）. METHODS：71 casesof adult non-severe CAP were selected and divided intolevofloxacingroup（group A，33 cases）and cefoxitin group（group B，38 cases）.Gronp A received Mesylate levofloxacin injection 200 ml inotraveously，oncea day；group B received Cefoxitin for injection 2.0 g intravenously，3 timesa day，for 8 days.Clinical efficacy，excellence time and ADR of 2 groups wereobserved，and cost-effectiveness analysis was conducted. RESULTS：Thetotal effective rate of group A and group B were 87.88％ and 65.79％，and excellence time（5.53±2.56）d and（3.87±3.03）d，with statistical significance（P＜0.05）；therewas no statistical significance in the incidence of ADR between 2 groups（χ2＝0.47，P＞0.05）.The total costs were 6 748.93 yuan and 8 110.34 yuan；the cost-effectiveness ratios were 76.80 and123.28；incremental cost-effectivenessratio was － 61.63％ .Results of sensitivity analysis matched results of cost-effectiveness analysis.CONCLUSIONS：Levofloxacin save more and is economical in the treatment of adultnon-severe CAP.社区获得性肺炎（Community-acquiredpneumonia，CAP）是指在医院外罹患的感染性肺实质（含肺泡壁，即广义上的肺间质）炎症，包括具有明确潜伏期的病原体感染而在入院后潜伏期内发