学龄期儿童慢性咳嗽病因分布及临床特征研究.pdfVIP

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  • 2019-06-02 发布于江苏
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学龄期儿童慢性咳嗽病因分布及临床特征研究.pdf

学龄期儿童慢性咳嗽病因分布及临床特征研究 中文摘要 结论 1. 学龄期儿童慢性咳嗽常见单病因为UACS、CVA和PIC,双病因以CVA+UACS GERC EB 最多,占总病因三分之一; 和 相对成人较为少见。 2. CVA咳嗽特征以干咳、夜间咳嗽为主,运动后诱发咳嗽对CVA诊断敏感度高; UACS咳嗽时相以晨起和(或)睡前为主,咽部阳性体征对UACS具有提示性作用; PIC患者咳嗽性质和时相无明显特异性,但感染相关对PIC诊断提示作用较大。 3. CVA气道炎症为嗜酸性粒细胞炎症,AHR是CVA的基本特征,治疗后痰EOS AHR UACS PIC 下降明显,但 下降不明显; 和 为非嗜酸粒细胞性炎症,两者均存在一 定比例的AHR,治疗4周AHR多数转为阴性。 4. 不同病因慢性咳嗽中,评估咳嗽症状积分无差别,但咳嗽症状积分在一定程 度上与气道高反应性相关。 关键词:慢性咳嗽 临床特征 咳嗽变异性哮喘 气道激发试验 气道高反应 性 学龄期儿童 作 者:于兴梅 指导老师:郝创利 III Abstract Thecausesandclinicalfeaturesofchroni coughinschool-agechildren Thecausesandclinicalfeaturesofchroni coughin school-agechildren Abstract Objective 1.To explorethe diagnosti value of chroni features in common causes of chroni coughbyanalyzingcommoncausesandchroni characteristicsofschool-agechildrenwith chroni cough.. 2.To learn airway hyperresponsiveness, induced sputum eosinophils and other auxiliarycheckinthecharacteristicsofdifferentetiologyofchroni coughinchildrenand diagnosti valueofthechroni Methods The outpatientsin ChildrensHospitalAffiliated to SoochowUniversity fromMarch 2012toDecember2013newly diagnosedwith chroni coughwho cough4weeks, have noobvioussignsoflungandno abnormalchestradiograph areenrolledinthis study.The patients are carefully inquiriednow history, past history, familyhistory, personal history, previoustreatmentanda eptsystemati physicalexamination.Andthepatients stopusing inflammatory drugs two weeks, while did the sputum EOS count, pulmonary function, airway provocation test (BPT), skin allergy testing (SPT) and 24 hour

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